Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction

A green and facile synthesis of previously unreported C,N-disulfonated 5-amino pyrazoles was established through an iodine-catalyzed cascade reaction of easily accessible sulfonyl hydrazides, beta-ketonitriles, and sodium sulfinates. Diverse C,N-disulfonated 5-amino pyrazoles could be obtained in 38-88% yields. This methodology features green and mild conditions, broad substrate scope, and effortless work-up.

Automated summary

A green and facile method for the synthesis of previously unreported compounds has been established. This method offers broad substrate scope, high yields, mild reaction conditions, and effortless work-up.