期刊
NEUROIMAGE-CLINICAL
卷 10, 期 -, 页码 124-128出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2015.11.012
关键词
Lesion mapping; Infarct; Lesion size; Hemorrhage; Volumetry
类别
资金
- Deutsche Forschungsgemeinschaft [KA1258/10-1, KA1258/20-1]
- Open Access Publishing Fund of University of Tubingen
Knowledge of the typical lesion topography and volumetry is important for clinical stroke diagnosis as well as for anatomo-behavioral lesion mapping analyses. Here we used modern lesion analysis techniques to examine the naturally occurring lesion patterns caused by ischemic and by hemorrhagic infarcts in a large, representative acute stroke patient sample. Acute MR and CT imaging of 439 consecutively admitted right-hemispheric stroke patients from a well-defined catchment area suffering from ischemia (n = 367) or hemorrhage (n = 72) were normalized and mapped in reference to stereotaxic anatomical atlases. For ischemic infarcts, highest frequencies of stroke were observed in the insula, putamen, operculum and superior temporal cortex, as well as the inferior and superior occipito-frontal fascicles, superior longitudinal fascicle, uncinate fascicle, and the acoustic radiation. The maximum overlay of hemorrhages was located more posteriorly and more medially, involving posterior areas of the insula, Heschl's gyrus, and putamen. Lesion size was largest in frontal and anterior areas and lowest in subcortical and posterior areas. The large and unbiased sample of stroke patients used in the present study accumulated the different sub-patterns to identify the global topographic and volumetric pattern of right hemisphere stroke in humans. (C) 2015 The Authors. Published by Elsevier Inc.
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