期刊
WORLD JOURNAL OF UROLOGY
卷 40, 期 12, 页码 3029-3034出版社
SPRINGER
DOI: 10.1007/s00345-022-04181-2
关键词
Glycogen deposition; Benign prostatic hyperplasia; BOO; Bladder outlet obstruction; Detrusor; Urodynamic studies
This study aimed to evaluate glycogen deposition within the bladder wall in patients with bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH) and its correlation with urodynamic findings. The study found that there was increased detrusor glycogen deposition in patients with BOO due to BPH, but the amount of deposition did not correlate with symptom severity and duration or urodynamic findings.
Purpose A prospective case-control study was conducted to evaluate glycogen deposition within the detrusor and its correlation with the urodynamic findings in patients with bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH). Material and methods Data from 50 patients with BPH (Study Group) and 20 controls (Control Group) were analyzed. BOO was confirmed by pressure-flow studies. The main outcome was glycogen deposition within the bladder wall. Bladder tissue biopsies were obtained from all patients, and histological assessment of the detrusor glycogen content was performed using Periodate Acid Schiff's (PAS) stain. The obtained glycogen score ranged from 0 (no staining of glycogen granules) to 3 (staining of glycogen granules within the detrusor adjacent to the urothelium). Results Fifty patients and 20 controls were included. Increased glycogen deposition was observed in 37 (74%) and 2 (10%) patients in the Study and Control Group, respectively (p < 0.01, OR 25.6, 95% CI 5.2-125.8). In the subgroup analysis, no statistically significant difference was found between glycogen deposition score and IPSS, maximum detrusor pressure at maximum flow (PdetQmax) and duration of LUTS. In multivariate logistic regression, history of retention was the only variable which could predict high glycogen deposition (p = 0.019). Conclusions Our results demonstrate increased detrusor glycogen deposition in patients with BOO due to BPH, but the amount of deposition did not seem to correlate with symptom severity and duration or urodynamic findings.
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