期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 42, 页码 8280-8284出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob01425d
关键词
-
资金
- National Natural Science Foundation of China [21762039]
- Natural Science Foundation of Gansu Province [20JR5RA521]
A metal-free method for the regioselective synthesis of 2-thiolated quinolines from quinoline N-oxides in water at room temperature has been developed. This method demonstrates advantages such as wide functional group tolerance, short reaction times and simple operation.
A metal-free method for the regioselective synthesis of 2-thiolated quinolines from quinoline N-oxides in water at room temperature is developed. The reaction is conducted using benzenethiols as thiolation reagents in the presence of p-toluenesulfonyl chloride via p-toluenesulfonyl chloride-assisted tandem C-H bond activation, nucleophilic addition, deoxygenation and aromatization processes. This method does not require the use of metal catalysts and oxidants. It shows the advantages of wide functional group tolerance, short reaction times and simple operation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据