期刊
MULTIPLE SCLEROSIS AND RELATED DISORDERS
卷 8, 期 -, 页码 136-140出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2016.05.019
关键词
Body mass index; Multiple sclerosis; Obesity; Sex differences
资金
- National Multiple Sclerosis Society [RG-4256A4/2]
- National Multiple Sclerosis Society/American Brain Foundation [FAN 1761-A-1]
- American Brain Foundation
- NINDS [K08 NS079493]
Background: Adolescent obesity is a risk factor for multiple sclerosis (MS), but little is known about changes in body mass index (BMI) after MS onset. Objective: To assess the relationship between MS and longitudinal changes in BMI. Methods: We analyzed prospectively collected BMIs in a cohort of patients with adult-onset MS and matched adult healthy controls (HC) gathered from the same hospital network central clinical data registry. Results: We made three main observations. First, at baseline MS patients had a significantly higher BMI than HC (age- and sex-adjusted mean difference=0.57; 95% CI: 0.15, 0.99; p=0.008). Second, a significant age by MS status interaction was observed (p<0.0001), such that in MS, BMIs did not increase significantly higher in older individuals, whereas BMIs in HCs were higher with increasing age. Third, we observed sex-specific associations with disease severity: higher BMI was associated with higher cross-sectional EDSS in women, but with lower EDSS in men (p=0.003, N=758). There were no longitudinal associations between BMI and EDSS in either sex or in the entire cohort (p=0.65, N=772). Conclusion: After MS onset, patients may not experience age-expected increases in BMI. BMI may have sex-specific associations with MS disability scores. More refined measures of body composition are warranted in future studies to distinguish adiposity from muscle mass. (C) 2016 Elsevier B.V. All rights reserved.
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