4.8 Article

Cryo-EM structures of human m6A writer complexes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

m6A RNA methylation: from mechanisms to therapeutic potential

P. Cody He et al.

Summary: m(6)A, the most prevalent mRNA modification, regulates gene expression by influencing mRNA metabolism in various physiological and pathophysiological processes. It plays a multifaceted role in mRNA decay, translation, and transcription, highlighting its crucial importance in post-transcriptional gene expression regulation.

EMBO JOURNAL (2021)

Article Multidisciplinary Sciences

Role of Hakai in m6A modification pathway in Drosophila

Yanhua Wang et al.

Summary: The Drosophila m6A writer complex regulates alternative splicing of the Sex-lethal gene, with the potential E3 ligase Hakai interacting with the fly m6A writer complex and causing reduced m6A levels in Hakai mutant flies.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

Praveen Bawankar et al.

Summary: The E3 ligase Hakai is a conserved component of the m(6)A methyltransferase complex in Drosophila and human cells. Depletion of Hakai results in reduced m(6)A levels and altered functions, affecting sex determination in Drosophila.

NATURE COMMUNICATIONS (2021)

Article Biochemical Research Methods

Measurement of atom resolvability in cryo-EM maps with Q-scores

Grigore Pintilie et al.

NATURE METHODS (2020)

Review Biochemistry & Molecular Biology

The role of m6A RNA methylation in human cancer

Xiao-Yu Chen et al.

MOLECULAR CANCER (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

The m6A Writer: Rise of a Machine for Growing Tasks

Dario L. Balacco et al.

BIOCHEMISTRY (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2017 update

Pietro Boccaletto et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

Thomas D. Goddard et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

PDBsum: Structural summaries of PDB entries

Roman A. Laskowski et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

Jing Wen et al.

MOLECULAR CELL (2018)

Article Cell Biology

METTL3 regulates WTAP protein homeostasis

Melissa Sorci et al.

CELL DEATH & DISEASE (2018)

Letter Biochemical Research Methods

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Q. Zheng et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Multidisciplinary Sciences

Accurate model annotation of a near-atomic resolution cryo-EM map

Corey F. Hryc et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

Ping Wang et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex

Xiang Wang et al.

NATURE (2016)

Article Multidisciplinary Sciences

m6A RNA methylation promotes XIST-mediated transcriptional repression

Deepak P. Patil et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

Alexis Rohou et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan et al.

NATURE (2015)

Article Biochemical Research Methods

Mapping native disulfide bonds at a proteome scale

Shan Lu et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

Keiko Horiuchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres

JOURNAL OF STRUCTURAL BIOLOGY (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

TOPPView: An Open-Source Viewer for Mass Spectrometry Data

Marc Sturm et al.

JOURNAL OF PROTEOME RESEARCH (2009)

Article Biochemistry & Molecular Biology

EMAN2: An extensible image processing suite for electron microscopy

Guang Tang et al.

JOURNAL OF STRUCTURAL BIOLOGY (2007)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Identification of WTAP, a novel Wilms' tumour 1-associating protein

NA Little et al.

HUMAN MOLECULAR GENETICS (2000)