☆ 4.5 Article

Parallel detection of SARS-CoV-2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID-19 donors

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

Vivek Naranbhai et al.

Summary: This study shows that T cell responses to the Omicron variant are largely preserved in individuals with prior infection, vaccination, or booster vaccination, although a subset of individuals may experience a reduction in T cell reactivity to the Omicron spike protein.

CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

Markus Hoffmann et al.

Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly and shows resistance to most therapeutic antibodies. It also evades neutralization by antibodies induced by infection or vaccination more efficiently than the Delta variant. This suggests that therapeutic antibodies may not be effective against the Omicron variant, and double vaccination with BNT162b2 may not provide adequate protection against severe disease caused by this variant.

CELL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

Sarah Adamo et al.

Summary: Researchers used spectral flow cytometry combined with cellular indexing of transcriptomes and T cell receptor sequencing to longitudinally characterize individual SARS-CoV-2-specific CD8(+) T cells from patients with COVID-19, identifying a distinct signature marking long-lived memory CD8(+) T cells. The study found that SARS-CoV-2-specific memory CD8(+) T cells persisting 1 year after acute infection express specific markers and exhibit characteristics resembling effector memory T cells, and that certain transcriptional signatures and signaling pathways are associated with the fate of individual clones of these cells.

NATURE (2022)

添加到收藏夹

Review Cell Biology

Association of HLA gene polymorphism with susceptibility, severity, and mortality of COVID-19: A systematic review

Paroma Deb et al.

Summary: HLA plays a role in COVID-19 susceptibility, severity, and mortality, but conclusive evidence is lacking due to heterogeneity in study designs and HLA typing methods. More uniformly designed, interrelated studies with global data are needed to support evidence-based medicine.

HLA (2022)

添加到收藏夹

Article Immunology

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients

Corine H. GeurtsvanKessel et al.

Summary: This study demonstrates that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, despite low levels of neutralizing antibodies. Booster vaccinations can partially restore cross-neutralization of the Omicron variant.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2-Specific Vaccine Candidates; the Contribution of Structural Vaccinology

Su Min Pack et al.

Summary: The production of SARS-CoV-2 vaccines and the use of structural vaccinology are discussed in this article. Cryo-electron microscopy plays a crucial role in vaccine development by providing three-dimensional structures of the virus and enabling the design of new candidates to combat emerging mutants. The development of vaccines to halt the COVID-19 pandemic is a milestone for the design and manufacturing of pan-coronavirus vaccines.

VACCINES (2022)

添加到收藏夹

Article Virology

Molecular evolutionary characteristics of SARS-CoV-2 emerging in the United States

Shihang Wang et al.

Summary: Through bioinformatics analysis of SARS-CoV-2 in the United States, this study revealed the nucleotide mutation rate, evolution rate, and mutation site characteristics of the S protein, providing insights for future surveillance and prevention of virus variants.

JOURNAL OF MEDICAL VIROLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Roanne Keeton et al.

Summary: Despite reduced neutralizing antibody activity, T cell responses induced by vaccination or infection can cross-recognize the Omicron variant and provide protection.

NATURE (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells

Anastasia A. Minervina et al.

Summary: Thomas and colleagues explore the impact of multiple SARS-CoV-2 antigen exposures on T cell immunity. They find that vaccination after infection leads to expansion of spike-specific T cells, while individuals after breakthrough infection mount vigorous non-spike-specific responses. They also observe that all exposures elicit diverse T cell immune repertoires, with no evidence of repertoire narrowing from repeated exposure.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

Garry Dolton et al.

Summary: This study examined the CD8 T cell response against a specific epitope of the Spike glycoprotein of SARS-CoV-2 and found that a specific mutation was not recognized by the majority of HLA A*02(+) convalescent patients and vaccinated individuals. This highlights the potential problem of viral escape at prevalent T cell epitopes restricted by high frequency HLAs and suggests the inclusion of multiple viral proteins in next generation vaccines. Monitoring T cell escape in new SARS-CoV-2 variants is crucial.

CELL (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection

Louise C. Rowntree et al.

Summary: This study explores the SARS-CoV-2-specific T cell memory in convalescent children with COVID-19. The results show that unvaccinated convalescent children have similar specific T cell responses as adults, but with lower responses to ORF1a and N. Additionally, children with seroconversion have a stem cell memory phenotype and common T cell receptor motifs in their specific T cells.

IMMUNITY (2022)

添加到收藏夹

Article Immunology

CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques

Jinyan Liu et al.

Summary: This study demonstrates that vaccine-elicited CD8+ T cells contribute substantially to virologic control after SARS-CoV-2 challenge in macaques.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Annika Nelde et al.

Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Evolution of antibody immunity to SARS-CoV-2

Christian Gaebler et al.

Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Mads Delbo Larsen et al.

Summary: This study reveals that afucosylated IgG antibodies are specifically formed against enveloped viruses, but not generally against other antigens. These antibodies enhance Fc gamma RIIIa responses, but also exacerbate cytokine storms and immune-mediated pathologies.

SCIENCE (2021)

添加到收藏夹

Article Cell Biology

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Anthony T. Tan et al.

Summary: This study found that early induction of interferon-gamma (IFN-gamma) secreting SARS-CoV-2-specific T cells was present in patients with mild disease and accelerated viral clearance, while rapid induction and quantity of humoral responses were associated with an increase in disease severity. These findings highlight the importance of early functional SARS-CoV-2-specific T cells in both vaccine design and immune monitoring.

CELL REPORTS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

SARS-CoV-2 specific CD8+ T cell responses in convalescent COVID-19 individuals

Hassen Kared et al.

Summary: Characterization of T cell responses in convalescent individuals from SARS-CoV-2 infection revealed unique phenotypes and a coordinated immune response, with specific CD8(+) T cell responses directed against various epitopes from the virus proteome. The differentiation of T cells into stem cell and transitional memory subsets may be crucial for developing lasting protection against the virus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses

Benedikt Agerer et al.

Summary: The study identified nonsynonymous mutations in MHC-I-restricted CD8(+) T cell epitopes of SARS-CoV-2 virus isolates, which resulted in diminished MHC-I binding of mutant peptides. This led to decreased proliferation, IFN-gamma production, and cytotoxic activity of CD8(+) T cells, along with qualitative differences in the transcriptional response to mutant peptides. These findings highlight the ability of SARS-CoV-2 to evade CD8(+) T cell surveillance through point mutations in MHC-I-restricted viral epitopes.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi H. O. Nguyen et al.

Summary: This study characterized CD8(+) T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed individuals, revealing that CD8(+) T cells specific for the immunodominant B7/N-105 epitope were detected at high frequencies both before and during acute COVID-19 and convalescence. The research also showed high naive precursor frequency and TCR alpha beta diversity within immunodominant B7/N-105-specific CD8(+) T cells, shedding light on the origins and responses of SARS-CoV-2-specific T cells.

IMMUNITY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Thushan de Silva et al.

Summary: Variants within dominant SARS-CoV-2 T cell epitopes have been identified through global sequence data analysis. These variants, independently arising in multiple lineages, result in loss of T cell recognition of specific epitopes. The findings demonstrate the potential for T cell evasion and emphasize the importance of ongoing surveillance for variants capable of escaping immune responses.

ISCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

Anastasia Gangaev et al.

Summary: This study identified a range of SARS-CoV-2 CD8(+) T cell responses across COVID-19 patients, including an epitope from ORF1ab with immunodominant features. The specific CD8(+) T cell responses can still be detectable up to 5 months after recovery from critical and severe disease, converting from dysfunctional effector cells to functional memory cells during convalescence.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

Sunil Kumar Saini et al.

Summary: This study experimentally evaluated MHC class I-binding peptides covering the complete SARS-CoV-2 genome, revealing significant CD8(+) T cell recognition of SARS-CoV-2 epitopes in patients with COVID-19, coupled with strong activation features in these T cells. Compared to healthy individuals, patients with severe disease displayed larger populations of SARS-CoV-2-specific T cells.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

SARS-CoV-2-specific CD8+ T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Louise C. Rowntree et al.

Summary: This study identified novel HLA-A*24:02-restricted epitopes of SARS-CoV-2 and characterized the CD8(+) T-cell responses associated with this HLA allomorph during COVID-19. The frequencies of A24/SARS-CoV-2-specific CD8(+) T cells increased substantially during COVID-19, showing effector and memory phenotypes. Ex vivo analyses of TCR alpha beta repertoires revealed distinct differences in repertoire diversity among COVID-19 patients for different epitopes.

IMMUNOLOGY AND CELL BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Dami A. Collier et al.

Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Valerie Oberhardt et al.

Summary: After vaccination, CD8(+) T cells become important effector cells in providing early protection, being effectively mobilized one week after primary vaccination and maintaining stability after booster vaccination. Compared with natural infection, vaccine-induced CD8(+) T cells exhibit similar functional capacities but with a different subset distribution.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Ugur Sahin et al.

Summary: The BNT162b2 vaccine shows 95% efficacy in preventing COVID-19 by boosting neutralizing antibody titres and activating specific T cell responses. The vaccine-induced immune response is broad and stable, lasting for a prolonged period, providing good coverage against various SARS-CoV-2 variants.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

Jae Hyung Jung et al.

Summary: The study reveals that memory T cell responses can be detected in convalescent COVID-19 patients up to 317 days post-symptom onset, indicating potential long-lasting immunity, especially with the presence of stem cell-like memory T cells.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 variants of concern partially escape humoral but not T- cell responses in COVID-19 convalescent donors and vaccinees

Daryl Geers et al.

Summary: This study suggests that some variants might partially escape humoral immunity induced by SARS-CoV-2 infection or BNT162b2 vaccination, but the S-specific CD4(+) T-cell activation is not affected by the mutations in the B.1.1.7 and B.1.351 variants.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

Alison Tarke et al.

Summary: The study showed that SARS-CoV-2 variants do not significantly disrupt total T cell reactivity, although decreases in response frequency of 10%-22% were observed under certain assay/VOC combinations. This underscores the importance of actively monitoring T cell responses in the context of SARS-CoV-2 evolution.

CELL REPORTS MEDICINE (2021)

添加到收藏夹

Article Immunology

Dynamics of antibodies to SARS-CoV-2 in convalescent plasma donors

Maurice Steenhuis et al.

Summary: The study found that most convalescent individuals were seropositive at the initial sampling, with only one seroreverting during follow-up analysis. Antibody levels declined 2-5 months after symptom onset, with a slowing rate of decline during extended follow-up indicating long-term immunological memory.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos et al.

Summary: The study found that the immune response in COVID-19 patients differs between the acute phase and convalescent phase, with more severe immune activation and cellular hyperactivation in critically ill patients. The research also revealed the crucial role of activated CXCR3(+)cT(FH)1 cells in predicting antibody levels and neutralization activity.

CELL REPORTS MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

Alison Tarke et al.

Summary: By studying T cell responses in 99 convalescent COVID-19 cases, we identified various HLA-restricted epitopes derived from SARS-CoV-2 and observed distinct patterns of immunodominance. The epitopes were combined into megapools to facilitate the identification and quantification of virus-specific CD4(+) and CD8(+) T cells.

CELL REPORTS MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells

Isabel Schulien et al.

Summary: The study found that SARS-CoV-2 infection induces and forms functionally competent memory CD8(+) T cell responses, which can persist in some SARS-CoV-2 convalescent individuals. Even in the absence of virus-specific antibodies, these virus epitope-specific CD8(+) T cell responses are induced following infection.

NATURE MEDICINE (2021)

添加到收藏夹

Article Microbiology

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

Alba Grifoni et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Editorial Material Immunology

Serum IgA, IgM, and IgG responses in COVID-19

Huan Ma et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Irani Thevarajan et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Immunology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

Daniela Weiskopf et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew et al.

SCIENCE (2020)

添加到收藏夹

Article Immunology

Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein

Andrew P. Ferretti et al.

IMMUNITY (2020)

添加到收藏夹

Article Immunology

Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Yanchun Peng et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R. Habel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Medicine, Research & Experimental

High levels of SARS-CoV-2-specific T cells with restricted functionality in severe courses of COVID-19

David Schub et al.

JCI INSIGHT (2020)

添加到收藏夹

Article Immunology

Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19

Erik H. Vogelzang et al.

JOURNAL OF IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemical Research Methods

ImmunomeBrowser: a tool to aggregate and visualize complex and heterogeneous epitopes in reference proteins

Sandeep Kumar Dhanda et al.

BIOINFORMATICS (2018)

添加到收藏夹

Article Virology

Differential Recognition of Influenza A Viruses by M158-66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues

Carolien E. van de Sandt et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Review Virology

Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

Carolien E. van de Sandt et al.

VIRUSES-BASEL (2012)

添加到收藏夹

Article Biochemical Research Methods

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers

Sine Reker Hadrup et al.

NATURE METHODS (2009)

添加到收藏夹

Article Biochemical Research Methods

Predicting population coverage of T-cell epitope-based diagnostics and vaccines

Huynh-Hoa Bui et al.

BMC BIOINFORMATICS (2006)

添加到收藏夹

Article Biochemical Research Methods

Generation of peptide-MHC class I complexes through UV-mediated ligand exchange

Boris Rodenko et al.

NATURE PROTOCOLS (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.