期刊
HUMAN GENOMICS
卷 16, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40246-022-00418-8
关键词
Bipolar disorder; Mood disorders; Accelerated aging; Cellular systems; Neural precursors; Lymphoblastoid cell liens; Lithium; In vitro; Aging; Telomeres
资金
- Sardinian Regional Government
This study used patients-derived lymphoblastoid cell lines to investigate the role of lithium in bipolar disorder (BD). The results showed no difference in telomere length between patients and controls after lithium treatment, suggesting that patients-derived lymphoblastoid cell lines may not be suitable for studying telomere dynamics in BD.
Background It has been suggested that bipolar disorder (BD) is associated with clinical and biological features of accelerated aging. In our previous studies, we showed that long-term lithium treatment was correlated with longer leukocyte telomere length (LTL) in BD patients. A recent study explored the role of TL in BD using patients-derived lymphoblastoid cell lines (LCLs), showing that baseline TL was shorter in BD compared to controls and that lithium in vitro increased TL but only in BD. Here, we used the same cell system (LCLs) to explore if a 7-day treatment protocol with lithium chloride (LiCl) 1 mM was able to highlight differences in TL between BD patients clinically responders (Li-R; n = 15) or non-responders (Li-NR; n = 15) to lithium, and if BD differed from non-psychiatric controls (HC; n = 15). Results There was no difference in TL between BD patients and HC. Moreover, LiCl did not influence TL in the overall sample, and there was no difference between diagnostic or clinical response groups. Likewise, LiCl did not affect TL in neural precursor cells from healthy donors. Conclusions Our findings suggest that a 7-day lithium treatment protocol and the use of LCLs might not represent a suitable approach to deepen our understanding on the role of altered telomere dynamics in BD as previously suggested by studies in vivo.
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