Prevalence and coagulation correlation of anticardiolipin antibodies in patients with COVID-19

We aimed to determine prevalence and characteristics of anticardiolipin antibodies (ACLs) and its correlations with laboratory coagulation variables in patients with coronavirus disease 2019 (COVID-19). We retrospectively analyzed the prevalence of serum ACLs and its correlation with coagulative laboratory variables in 87 patients with COVID-19. ACLs were detected in 13/21 (61.91%) critically ill patients, and 21/66 (31.82%) in non-critically ill patients. For ACLs, IgA, and IgG were the most common types. The prevalence of IgG in critical ill patients was much higher than that in non-critical patients with odd ratio = 2.721. And the levels of all isotypes of ACLs in critically ill patients were much higher than those in non-critically ill patients. Correlation analysis showed that activated partial thromboplastin time and thrombin time had weak correlation with ACLs-IgG (R = 0.308, P = .031; R = 0.337, P = .018, respectively). Only the prevalence of ACLs-IgG shows a significant difference when compared critically ill patients with non-critically ill patients. ACLs do not seem to have a clear correlation with thrombosis occurred in COVID-19 patients.

Automated summary

The study aimed to investigate the prevalence and characteristics of anticardiolipin antibodies (ACLs) in patients with COVID-19, as well as its correlation with laboratory coagulation variables. The results showed that the prevalence and levels of ACLs were significantly higher in critically ill patients compared to non-critically ill patients. Correlation analysis revealed a weak correlation between ACLs-IgG and activated partial thromboplastin time, as well as thrombin time. However, ACLs do not seem to have a clear correlation with thrombosis occurred in COVID-19 patients.