A copper-catalyzed three-component reaction of dithioacetals with diazo ketones and ketimines

A copper-catalyzed three-component reaction of dithioacetals with diazo-ketones and ketimines has been reported. This reaction proceeds via trapping of the highly active sulfur ylide species, which are generated from thioacetal and carbene intermediates, with isatin-derived ketimine, providing an efficient protocol for the synthesis of acyclic thioacetal derivatives and medium-sized sulfur-containing heterocycles in good to high yields under mild reaction conditions with a broad substrate scope.

Automated summary

A copper-catalyzed three-component reaction has been reported for the synthesis of acyclic thioacetal derivatives and medium-sized sulfur-containing heterocycles. The reaction proceeds by trapping highly active sulfur ylide species with isatin-derived ketimine, providing a broad substrate scope and good to high yields under mild reaction conditions.