A simple and low-cost electrochemical sensor based on a graphite sheet electrode modified by carboxylated multiwalled carbon nanotubes and gold nanoparticles for detection of acyclovir

A low cost sensitive electrochemical sensor based on functionalized carbon nanotubes and Au nanoparticles deposited on commercial graphite sheets for detection of an antiviral drug, acyclovir (ACV), in pharmaceutical preparations has been developed. The surface morphology of the fabricated electrode was assessed by FT-IR spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). This developed sensor exhibited excellent activity for the electrochemical oxidation of ACV. Both CV and linear sweep voltammetry (LSV) were employed to study the electrocatalytic properties of the modified AuNPs/CNTs-COOH/GSE to elucidate the oxidation behavior of ACV. The fabricated sensor exhibited excellent electro-catalytic activity toward ACV determination in pharmaceutical preparations in a wide concentration range of 0.19 mu M to 200 mu M. Two linear ranges have been obtained for the acyclovir concentration: 0.19-52 mu M and 52-200 mu M, with a detection limit of 0.007 mu M. The lower linear concentration range of 0.19-52 mu M showed a sensitivity of 2.18 A M-1 cm(-2), and the other one from 52 mu M to 200 mu M showed a sensitivity of 0.268 A M-1 cm(-2). The AuNPs/CNTs-COOH/GSE sensor has been applied for determination of ACV in pharmaceutical preparations. The method presents good sensitivity and stability suitable for routine quantification of drugs in pharmaceutical formulations.

Automated summary

A low-cost electrochemical sensor based on carbon nanotubes and gold nanoparticles has been developed for the detection of the antiviral drug acyclovir in pharmaceutical preparations. The sensor exhibited excellent sensitivity towards ACV and can be used for routine quantification of drugs in pharmaceutical formulations.