期刊
GREEN CHEMISTRY
卷 24, 期 21, 页码 8434-8440出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc02767d
关键词
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资金
- Swiss National Science Foundation (SNSF) [200021_192274]
- Universitat Bern
- Swiss National Science Foundation (SNF) [200021_192274] Funding Source: Swiss National Science Foundation (SNF)
This study introduces a novel chemoenzymatic strategy for the rapid synthesis of valuable plant chemical compound hordenine, reducing environmental impact and improving production rate.
To improve sustainability, safety and cost-efficiency of synthetic methodologies, biocatalysis can be a helpful ally. In this work, a novel chemoenzymatic stategy ensures the rapid synthesis of hordenine, a valuable phenolic phytochemical under mild working conditions. In a two-step cascade, the immobilized tyrosine decarboxylase from Lactobacillus brevis (LbTDC) is here coupled with the chemical reductive amination of tyramine. Starting from the abundant and cost-effective amino acid l-tyrosine, the complete conversion to hordenine is achieved in less than 5 minutes residence time in a fully-automated continuous flow system. Compared to the metal-catalyzed N,N-dimethylation of tyramine, this biocatalytic approach reduces the process environmental impact and improves its STY to 2.68 g L-1 h(-1).
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