4.7 Article

Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 -, 期 -, 页码 -

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/ijac368

关键词

AIM; PBMC; anti-phage antibody; bacteriophage; immune response; phage therapy; T follicular helper cell

资金

  1. National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health [K08 AI135078, U19 AI142742]

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This study reported a case of successful treatment of multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient using phage therapy. The development of phage-specific immune response was observed.
Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4(+) T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.

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