Design, Synthesis and Seed Germination Inhibition Activity of Quinoline-6-sulfonamide Compounds

To develop novel abscisic acid (ABA) functional mimics, a series of quinoline-6-sulfonamide compounds 3 and 4 was designed based on the principle of active substructure splicing with ABA mimic 1 (AM1) and pyrabactin as lead compounds. The low-cost and commercial quinoline was used as starting material to offer the novel compounds via the salifying, oxidation, hydrogenation, sulfonylation, amination. Additionally, all the target compounds could inhibit soybean seed germination at the concentration of 50 mu mol.L-1. Furthermore, the compounds 3, 4b, 4h, 4i could inhibit soybean seed germination overwhelmingly at 25 mu mol.L-1. These results are benefit to discovering novel and high activity of ABA functional mimics.

Automated summary

A series of quinoline-6-sulfonamide compounds were designed based on the principle of active substructure splicing with ABA mimic and pyrabactin as lead compounds. These compounds could inhibit soybean seed germination and hold potential for discovering novel and highly active ABA functional mimics.