SCF3 Radical Initiated Cascade Reaction of Unsaturated Hydrocarbon

Fluorinated compounds have been widely used in pharmaceuticals, pesticides and other disciplines due to their special physical and chemical properties, which motivates the frequent introduction of fluorinated functionalities into lead compounds to improve their physical and chemical properties. The trifluoromethylthio (SCF3) group with high electronegativity and special lipophilicity plays an important role in a multitude of fluorinated compounds. The recent progress in the field of cascade reaction of unsaturated hydrocarbon initiated by SCF3 radical, including reaction design, reaction mechanism and outlook, is summarized.

Automated summary

Fluorinated compounds are widely used in various fields due to their unique physical and chemical properties. The introduction of fluorinated functionalities into lead compounds has become a common strategy to enhance their properties. The trifluoromethylthio (SCF3) group, known for its high electronegativity and special lipophilicity, plays a crucial role in numerous fluorinated compounds. This article summarizes the recent progress in the cascade reaction of unsaturated hydrocarbons initiated by SCF3 radicals.