Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview

MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been in a nascent state. MiRNAs play a significant role in the pathogenesis of Type 2 diabetes mellitus establishing the potential for utilizing miRNA-based therapeutic interventions to treat the disease. Recently, the administration of miRNA mimics or antimiRs in-vivo has resulted in positive modulation of glucose and lipid metabolism. Further, several cell culture-based interventions have suggested beta cell regeneration potential in miRNAs. Nevertheless, few such miRNA-based therapeutic approaches have reached the clinical phase. Therefore, future research contributions would identify the possibility of miRNA therapeutics for tackling T2DM. This article briefly reported recent developments on miRNA-based therapeutics for treating Type 2 Diabetes mellitus, associated implications, gaps, and recommendations for future studies.

Automated summary

MicroRNA (miRNA) has the potential to be a therapeutic intervention for Type 2 diabetes mellitus due to its stable presence in humans and animals and its ability to regulate glucose and lipid metabolism. However, there is still a lack of clinical-phase miRNA-based therapeutic approaches for treating this disease. Future research should focus on identifying the possibility of miRNA therapeutics for tackling Type 2 diabetes mellitus.