期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 42, 页码 8664-8671出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb01436j
关键词
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资金
- National Natural Science Foundation of China [51825302, 21734002, 51802202, 21807074]
- Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002]
- Chongqing Talents: Youth Top-notch Talent Project [cstc2022ycjh-bgzxm0167]
The study presents a multifunctional nanoreactor that possesses the capabilities of nutrient consumption, generation of reactive oxygen species (ROS), and promotion of angiogenesis for antibacterial effects and skin wound repair. The nanoreactor is able to consume bacterial nutrients through oxidation reactions and kill bacteria through a Fenton-like reaction, while promoting angiogenesis for accelerated wound healing by releasing Zn2+.
Bacterial wound infection has brought a serious threat to human health and caused huge economic losses. Attempts to develop biomaterials with excellent antibacterial effects are meaningful to promote wound healing. Herein, we report a multifunctional nanoreactor with nutrient consumption and reactive oxygen species (ROS) generation capabilities for antibacterial and skin wound repair. The nanoreactor was constructed by the encapsulation of glucose oxidase (GOx) into a Cu2+-doped zeolite-based imidazole framework (ZIF-8) through a one-pot synthesis method. The nanoreactor not only consumes the nutrients of bacteria by the GOx-driven oxidation reaction, but also generates highly toxic hydroxyl radicals (OH) to kill bacteria via a Cu+-mediated Fenton-like reaction. Moreover, Zn2+ released from the nanoreactor is also capable of exhibiting synergistic antibacterial activity. In addition to mediating Fenton-like reactions, Cu2+ promotes angiogenesis to accelerate wound healing. Thus, the multifunctional nanoreactor has the ability to cut off the nutrient supply and starve the bacteria, produce ROS to kill bacteria, and promote angiogenesis to accelerate wound healing, enabling it to be promising for the treatment of wound infection.
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