期刊
KOREAN JOURNAL OF INTERNAL MEDICINE
卷 31, 期 6, 页码 1009-1017出版社
KOREAN ASSOC INTERNAL MEDICINE
DOI: 10.3904/kjim.2016.078
关键词
Mean platelet volume; Atrial fibrillation; Ischemic stroke; Coronary artery disease; Percutaneous coronary intervention
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future Planning [2016R1A2B4011905]
- Ministry of Education, Science and Technology [2014028083]
- National Research Foundation of Korea [2016R1A2B4011905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.
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