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NATURE METHODS (2015)
Robust enumeration of cell subsets from tissue expression profiles
Aaron M. Newman et al.
NATURE METHODS (2015)
Neural plasticity in pancreatitis and pancreatic cancer
Ihsan Ekin Demir et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)
UNDO: a Bioconductor R package for unsupervised deconvolution of mixed gene expressions in tumor samples
Niya Wang et al.
BIOINFORMATICS (2015)
An assessment of computational methods for estimating purity and clonality using genomic data derived from heterogeneous tumor tissue samples
Vinod Kumar Yadav et al.
BRIEFINGS IN BIOINFORMATICS (2015)
Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?
Jo Nijs et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2015)
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
David Quigley et al.
MOLECULAR CANCER RESEARCH (2015)
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
Biao Ma et al.
NATURE CELL BIOLOGY (2015)
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth
V. De Simone et al.
ONCOGENE (2015)
HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer
Wenjing Zhang et al.
PLOS ONE (2015)
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
Jessie S. Jeon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Microfluidic 3D models of cancer
Kyung Eun Sung et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples
David A. Liebner et al.
BIOINFORMATICS (2014)
OptiType: precision HLA typing from next-generation sequencing data
Andras Szolek et al.
BIOINFORMATICS (2014)
Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape
Thomas J. Long et al.
BIOMATERIALS (2014)
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
Jian Guan et al.
CANCER LETTERS (2014)
Clinical significance of macrophage heterogeneity in human malignant tumors
Yoshihiro Komohara et al.
CANCER SCIENCE (2014)
Organoid Cultures Derived from Patients with Advanced Prostate Cancer
Dong Gao et al.
CELL (2014)
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman et al.
CELL (2014)
NetTepi: an integrated method for the prediction of T cell epitopes
Thomas Trolle et al.
IMMUNOGENETICS (2014)
Exploiting the curative potential of adoptive T-cell therapy for cancer
Christian S. Hinrichs et al.
IMMUNOLOGICAL REVIEWS (2014)
Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology
Bartley J. Gill et al.
JOURNAL OF BIOMECHANICS (2014)
Microfluidic organs-on-chips
Sangeeta N. Bhatia et al.
NATURE BIOTECHNOLOGY (2014)
Niche-independent high-purity cultures of Lgr5(+) intestinal stem cells and their progeny
Xiaolei Yin et al.
NATURE METHODS (2014)
Towards error-free profiling of immune repertoires
Mikhail Shugay et al.
NATURE METHODS (2014)
Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
John C. Morris et al.
PLOS ONE (2014)
Development of an Acellular Tumor Extracellular Matrix as a Three-Dimensional Scaffold for Tumor Engineering
Wei-Dong Lu et al.
PLOS ONE (2014)
Organogenesis in a dish: Modeling development and disease using organoid technologies
Madeline A. Lancaster et al.
SCIENCE (2014)
Denervation suppresses gastric tumorigenesis
Chun-Mei Zhao et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Improved Survival with T Cell Clonotype Stability After Anti-CTLA-4 Treatment in Cancer Patients
Edward Cha et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
Daniel Ackerman et al.
TRENDS IN CELL BIOLOGY (2014)
Quantitative reconstruction of leukocyte subsets using DNA methylation
William P. Accomando et al.
GENOME BIOLOGY (2014)
The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance
Douglas T. Fearon
CANCER IMMUNOLOGY RESEARCH (2014)
Cell Transfer Therapy for Cancer: Past, Present, and Future
Xiaoling Qian et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2014)
Are natural killer cells superior CAR drivers?
Hans Klingemann
ONCOIMMUNOLOGY (2014)
Dendritic cell immunotherapy
Rachel Lubong Sabado et al.
RENAISSANCE OF CANCER IMMUNOTHERAPY (2013)
DeMix: deconvolution for mixed cancer transcriptomes using raw measured data
Jaeil Ahn et al.
BIOINFORMATICS (2013)
PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data
Nicholas B. Larson et al.
BIOINFORMATICS (2013)
DeconRNASeq: a statistical framework for deconvolution of heterogeneous tissue samples based on mRNA-Seq data
Ting Gong et al.
BIOINFORMATICS (2013)
BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Chengwen Liu et al.
CLINICAL CANCER RESEARCH (2013)
The potential of sunitinib as a therapy in ovarian cancer
Umberto Leone Roberti Maggiore et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)
Defining cell-type specificity at the transcriptional level in human disease
Wenjun Ju et al.
GENOME RESEARCH (2013)
Expansion of breast cancer stem cells with fibrous scaffolds
Sheng Feng et al.
INTEGRATIVE BIOLOGY (2013)
High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer
Ryan O. Emerson et al.
JOURNAL OF PATHOLOGY (2013)
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Kristian Cibulskis et al.
NATURE BIOTECHNOLOGY (2013)
IgBLAST: an immunoglobulin variable domain sequence analysis tool
Jian Ye et al.
NUCLEIC ACIDS RESEARCH (2013)
Autonomic Nerve Development Contributes to Prostate Cancer Progression
Claire Magnon et al.
SCIENCE (2013)
Inferring tumour purity and stromal and immune cell admixture from expression data
Kosuke Yoshihara et al.
NATURE COMMUNICATIONS (2013)
Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation
Philip Borden et al.
CELL REPORTS (2013)
A Self-Directed Method for Cell-Type Identification and Separation of Gene Expression Microarrays
Neta S. Zuckerman et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
Alexandre Boissonnas et al.
NEOPLASIA (2013)
Cancer-associated fibroblasts as targets for immunotherapy
Sunitha Kakarla et al.
IMMUNOTHERAPY (2012)
Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin
Chi-Ping Day et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer
Dong Tang et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
The extracellular matrix: A dynamic niche in cancer progression
Pengfei Lu et al.
JOURNAL OF CELL BIOLOGY (2012)
Interleukin-21 Has Activity in Patients With Metastatic Melanoma: A Phase II Study
Teresa M. Petrella et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Targeting the TGFβ signalling pathway in disease
Rosemary J. Akhurst et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions
Wenlian Qiao et al.
PLOS COMPUTATIONAL BIOLOGY (2012)
Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation
Erin M. Bekes et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Immunological network signatures of cancer progression and survival
Trevor Clancy et al.
BMC MEDICAL GENOMICS (2011)
The significant role of mast cells in cancer
Khashayarsha Khazaie et al.
CANCER AND METASTASIS REVIEWS (2011)
HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Julie Mathieu et al.
CANCER RESEARCH (2011)
LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution
Holly E. Barker et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
Joseph P. Ritchie et al.
CLINICAL CANCER RESEARCH (2011)
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Steven A. Rosenberg et al.
CLINICAL CANCER RESEARCH (2011)
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Toshiro Sato et al.
GASTROENTEROLOGY (2011)
Cancer Immunotherapy Comes of Age
Suzanne L. Topalian et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
Peter M. Rothwell et al.
LANCET (2011)
Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain
Alexandre Kuhn et al.
NATURE METHODS (2011)
From 3D cell culture to organs-on-chips
Dongeun Huh et al.
TRENDS IN CELL BIOLOGY (2011)
Probabilistic analysis of gene expression measurements from heterogeneous tissues
Timo Erkkila et al.
BIOINFORMATICS (2010)
Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Cyril Fauriat et al.
BLOOD (2010)
Hypoxia inducible factors in cancer stem cells
J. M. Heddleston et al.
BRITISH JOURNAL OF CANCER (2010)
Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers
Satoshi Tsunetoh et al.
CANCER BIOLOGY & THERAPY (2010)
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian et al.
CELL (2010)
HIF-1: upstream and downstream of cancer metabolism
Gregg L. Semenza
CURRENT OPINION IN GENETICS & DEVELOPMENT (2010)
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
Aaron McKenna et al.
GENOME RESEARCH (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Amar J. Majmundar et al.
MOLECULAR CELL (2010)
Cell type-specific gene expression differences in complex tissues
Shai S. Shen-Orr et al.
NATURE METHODS (2010)
Glycolytic metabolism and tumour response to fractionated irradiation
Ulrike G. A. Sattler et al.
RADIOTHERAPY AND ONCOLOGY (2010)
ISOLATE: a computational strategy for identifying the primary origin of cancers using high-throughput sequencing
Gerald Quon et al.
BIOINFORMATICS (2009)
Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian prior
Yohan Kim et al.
BMC BIOINFORMATICS (2009)
NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction
Morten Nielsen et al.
BMC BIOINFORMATICS (2009)
Integrated Data From 2 Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trials of Active Cellular Immunotherapy With Sipuleucel-T in Advanced Prostate Cancer
Celestia S. Higano et al.
CANCER (2009)
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
Theresa A. Ulrich et al.
CANCER RESEARCH (2009)
Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives
Zaher K. Otrock et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2009)
Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
Jack Cuzick et al.
LANCET ONCOLOGY (2009)
Local IL-21 Promotes the Therapeutic Activity of Effector T cells by Decreasing Regulatory T Cells Within the Tumor Microenvironment
Seunghee Kim-Schulze et al.
MOLECULAR THERAPY (2009)
Deconvolution of Blood Microarray Data Identifies Cellular Activation Patterns in Systemic Lupus Erythematosus
Alexander R. Abbas et al.
PLOS ONE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer
Gustavo E. Ayala et al.
CLINICAL CANCER RESEARCH (2008)
The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
Paola Allavena et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)
NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11
Claus Lundegaard et al.
NUCLEIC ACIDS RESEARCH (2008)
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Cecilia Sahlgren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
iHMMune-align:: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
Bruno A. Gaeta et al.
BIOINFORMATICS (2007)
Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage
Ivan Perrot et al.
JOURNAL OF IMMUNOLOGY (2007)
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
HK Erickson et al.
CANCER RESEARCH (2006)
Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: An AIDS Malignancy Consortium study
BJ Dezube et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells
JM Roda et al.
CANCER RESEARCH (2006)
Use of statins and breast cancer: A meta-analysis of seven randomized clinical trials and nine observational studies
S Bonovas et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Involvement of transforming growth factor-β1 signaling in hypoxia-induced tolerance to glucose starvation
A Suzuki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method
B Peters et al.
BMC BIOINFORMATICS (2005)
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
A Orimo et al.
CELL (2005)
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
NA Bhowmick et al.
SCIENCE (2004)
Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF
C LeBedis et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
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