期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 89, 页码 12459-12462出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04383a
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Japan Society for the Promotion of Science (JSPS) [18KK0164, 21H05109, 21K14742, 22H04975]
- JSPS Core-to-Core Program [JPJSCCA20220005]
- Hirao Taro Foundation of Konan Gakuen for Academic Research
- Chubei Itoh Foundation
Understanding the regulatory mechanisms of DNA methylation in response to environmental changes is crucial and urgent. This study reveals that G-quadruplex (G4) stability and topology play a role in DNA methylation regulation. The higher the stability of G4, the lower the methylation efficiency. Furthermore, the topology of G4 can also control the degree of methylation suppression. These findings suggest the possibility of regulating methylation by modulating G4 stability and topology.
Since DNA methylation alters the chromatin state and regulates gene expression, elucidating the regulatory mechanisms of DNA methylation in response to environmental changes in the cell is crucial and urgent in understanding and regulating DNA methylation. G-quadruplex (G4) regulates transcription, translation and replication. Although it has recently been suggested that G4 regulates methylation, the detailed regulatory mechanism remains unclear. Here, we systematically analysed the effect of G4 formation on DNA methylation using G4s with various stabilities and topologies. The methylation efficiency decreased as the stability of G4 increased. Moreover, the degree of methylation suppression can be also controlled by G4 topology. Furthermore, our results showed the possibility of regulating methylation by modulating G4 stability and topology.
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