期刊
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
卷 67, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/ijph.2022.1604616
关键词
data analysis; dietary vitamin K intake; human papillomavirus (HPV); HPV-infection; HPV-subtypes
资金
- Guizhou Provincial High-level Overseas Talents Innovation and Entrepreneurship Selection [(2018)-05]
This study observed the association between vitamin K intake and HPV infection, finding a nonlinearity between the two. An increase in log2 vitamin K intake of one unit was associated with a 43% reduction in the risk of HPV infection within the range of 0-3.81. However, the risk of HPV infection did not continue to decline when log2 vitamin K intake exceeded 3.81. There was no association between vitamin K intake and HPV subtype.
Objective: Cervical cancer is a serious potential risk to women's health, and is closely related to persistent HPV infection. Vitamin K mainly existed in green vegetables, fruit, and dairy products. This research aims to observe the association between vitamin K and HPV-infection.Methods: 13,447 participants from the NHANES were selected. Dietary vitamin K intake was used as the objective independent variable and continuous variable, HPV-infection status was used as the outcome variable, and characteristics of selected participants were used as the covariates.Results: There was a nonlinearity between vitamin K intake and HPV-infection, and the inflection point is 3.81 of log2 vitamin K intake. In a range of 0-3.81, Each one-unit increase in log2 vitamin K intake was associated with a 43% reduction in the risk of HPV infection. When log2 vitamin K intake excess of 3.81, the risk of HPV infection did not continue to decline. The HPV-subtype was not associated with vitamin K intake.Conclusion: There is a nonlinearity between vitamin K intake and HPV-infection status. But HPV-subtype was not associated with vitamin K intake.
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