4.4 Article

Novel DZ-SIM Conjugate Targets Cancer Mitochondria and Prolongs Survival in Pancreatic Ductal Adenocarcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy

Nan Wang et al.

Summary: Glioblastoma multiforme (GBM) is a highly malignant primary tumor of the central nervous system (CNS) with decreasing sensitivity to chemotherapy over time. Research has shown that under TMZ treatment, the oxidative phosphorylation (OXPHOS) level in GBM cells increases, influenced by factors such as mitochondrial morphology and AMPK.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Review Biology

A Review on the Efficacy and Safety of Nab-Paclitaxel with Gemcitabine in Combination with Other Therapeutic Agents as New Treatment Strategies in Pancreatic Cancer

Christian Chapa-Gonzalez et al.

Summary: Pancreatic cancer has a high mortality rate and combining nab-paclitaxel with gemcitabine is the standard first-line therapy. However, additional therapeutic agents are being studied to improve patient outcomes. This study compared the efficacy and safety of combining nab-paclitaxel with gemcitabine with other therapeutic agents in different clinical phases. Seven studies met the inclusion criteria, and the review aimed to determine the safest combination for previously untreated metastatic pancreas ductal adenocarcinoma.

LIFE-BASEL (2022)

Review Oncology

Systemic Therapy for Metastatic Pancreatic Cancer

Thomas J. Ettrich et al.

Summary: Pancreatic cancer is often diagnosed at an advanced stage with poor prognosis, but chemotherapy has shown improvement in both survival and quality of life. Recent advancements include effective combination therapy options and targeted treatments for specific genetic mutations, highlighting the importance of early genetic testing for better treatment decisions.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

Article Oncology

Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells

Liyuan Yin et al.

Summary: DZ-SIM is a promising novel therapy for NSCLC patients to overcome cisplatin and TKI resistance by targeting mitochondrial structure and function to induce cell death.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Review Neurosciences

Mitochondrial dynamics, mitophagy and cardiovascular disease

Cesar Vasquez-Trincado et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Oncology

HDAC3 mediates smoking-induced pancreatic cancer

Mouad Edderkaoui et al.

ONCOTARGET (2016)

Article Gastroenterology & Hepatology

Impact of Statin Use on Survival in Patients Undergoing Resection for Early-Stage Pancreatic Cancer

Bechien U. Wu et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2015)

Article Oncology

Near IR Heptamethine Cyanine Dye-Mediated Cancer Imaging

Xiaojian Yang et al.

CLINICAL CANCER RESEARCH (2010)

Review Pharmacology & Pharmacy

Statin use and cancer risk: a comprehensive review

Denise M. Boudreau et al.

EXPERT OPINION ON DRUG SAFETY (2010)

Article Multidisciplinary Sciences

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin

Mouad Edderkaoui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Gastroenterology & Hepatology

Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase

M Edderkaoui et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)