☆ 3.8 Review

Good practices for 68Ga radiopharmaceutical production

EJNMMI RADIOPHARMACY AND CHEMISTRY (2022)

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Demystifying solid targets: Simple and rapid distribution-scale production of [68Ga]GaCl3 and [68Ga]Ga-PSMA-11

Johan Svedjehed et al.

Summary: The study focused on a fully automated solid target production and purification process with a simplified chemistry execution using a single time-list. High activity productions of [Ga-68]GaCl3 achieved a high purification yield with good radiochemical yields, while [Ga-68]Ga-PSMA-11 productions also showed promising results in terms of yield and purity.

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Silvia Migliari et al.

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Examination of metallic impurities of 68Ge/68Ga generators used for radioactive labeling of peptides in clinical PET applications

Ayse Ugur et al.

Summary: Comparative analysis of metal contamination in the eluate of Ge-68/Ga-68 generators used in different centers in Turkey revealed that each generator contains metallic impurities different from its certificate.

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Recent Breakthrough in 68Ga-Radiopharmaceuticals Cold Kits for Convenient PET Radiopharmacy

Drishty Satpati

Summary: Ga-68-PET is crucial for detecting and monitoring oncological situations, with its availability and cost being key factors for success. The simplified production of Ga-68-radiopharmaceuticals from a generator allows for smooth accommodation in clinics. There is potential for development of kits and wider global usage.

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Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer

Leonardo L. Fuscaldi et al.

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Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers

Emma Jussing et al.

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[68Ga]Ga-PSMA-11: The First FDA-Approved 68Ga-Radiopharmaceutical for PET Imaging of Prostate Cancer

Ute Hennrich et al.

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Article Chemistry, Medicinal

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

Helge Thisgaard et al.

Summary: In response to the increasing clinical demand for gallium-68, a high-yield, automated method has been developed for producing multi-Curie levels of [Ga-68]GaCl3 from solid zinc-68 targets. This method led to record-high purified gallium-68 activities and successful labelling of PSMA-11 and DOTATATE, showing promising results for clinical use in terms of quality control.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

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Article Chemistry, Medicinal

Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals

Nic Gillings et al.

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Taking cyclotron 68Ga production to the next level: Expeditious solid target production of 68Ga for preparation of radiotracers

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Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

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Cyclotron production of 68Ga in a liquid target: Effects of solution composition and irradiation parameters

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Rapid and automated production of [68Ga]gallium chloride and [68Ga] Ga-DOTA-TATE on a medical cyclotron

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Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform

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Optimization of a Labeling and Kit Preparation Method for Ga-68 Labeled DOTATATE, Using Cation Exchange Resin Purified Ga-68 Eluates Obtained from a Tin Dioxide Ge-68/Ga-68 Generator

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