☆ 4.7 Review

3D bioprinted cancer models: from basic biology to drug development

NATURE REVIEWS CANCER (2022)

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Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

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Article Engineering, Biomedical

3D bioprinted drug-resistant breast cancer spheroids for quantitative in situ evaluation of drug resistance

Sera Hong et al.

Summary: Drug-resistant cancer spheroids were fabricated using 3D bioprinting to evaluate the drug resistance of cancer cells. The study successfully created drug-resistant breast cancer spheroids using a gelatin-alginate hydrogel and demonstrated that these spheroids maintained their drug-resistant characteristics. The research also showed that the drug-resistant spheroids had higher expression levels of drug resistance markers compared to bulk cancer spheroids. Additionally, the study developed a method to determine the efficacy of anticancer drugs using the EC50 values based on in situ fluorescence imaging of the spheroids. This research provides a new approach for drug screening and evaluation in cancer treatment.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures

Michael Hu et al.

Summary: This study integrates CRISPR-Cas-based genome engineering and biofabrication technologies to enable genetic screens in physiologically relevant ex vivo cancer tissue models. The results demonstrate that perfusable tissue constructs can be used for large-scale CRISPR screens and emulate clinically actionable gene knockout scenarios.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

In vitro breast cancer model with patient-specific morphological features for personalized medicine

Jonghyeuk Han et al.

Summary: This study developed a novel bioprinting technique to create an in vitro breast cancer model with patient-specific morphological features. The model accurately mimicked the cellular microstructures of heterogeneous cancer tissues and produced drug responses similar to human cancers.

BIOFABRICATION (2022)

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Article Engineering, Biomedical

3D bioprinted, vascularized neuroblastoma tumor environment in fluidic chip devices for precision medicine drug testing

Daniel Nothdurfter et al.

Summary: This paper presents a novel 3D printed neuroblastoma-tumor-environment model and a biofabrication platform suitable for studying tumor angiogenesis and metastasis.

BIOFABRICATION (2022)

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Article Chemistry, Multidisciplinary

A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor-Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior

Liqun Ning et al.

Summary: This study utilizes 3D bioprinting and NB spheroids to create a vascular model of NB with an endothelialized microenvironment. The results suggest that NB exhibits increased aggression in this model, and metabolic, cytokine, and gene expression profiles can be assessed under different TME conditions.

ADVANCED SCIENCE (2022)

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Article Polymer Science

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Ahmed Fatimi et al.

Summary: Three-dimensional printing is considered an important technology in tissue engineering, especially due to the growing demand for organ replacement and tissue regeneration. In 3D bioprinting, the ink used is impregnated with cells, allowing for immediate scaffold cellularization and generation of complex structures. This study comprehensively explores the use of bio-inks based on natural polymers in 3D bioprinting, discussing progress, techniques and approaches, as well as limitations and future trends.

GELS (2022)

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Article Engineering, Biomedical

Three-dimensional bio-printing of primary human hepatocellular carcinoma for personalized medicine

Feihu Xie et al.

Summary: This study established a modeling system using three-dimensional bioprinting technology for patient-specific drug screening for hepatocellular carcinoma. The models retained features of parental HCCs, including stable biomarker expression and genetic alterations. Additionally, the models were capable of intuitively and quantitatively displaying drug screening results.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Alginate-gelatin-Matrigel hydrogels enable the development and multigenerational passaging of patient-derived 3D bioprinted cancer spheroid models

Salvador Flores-Torres et al.

Summary: This study demonstrates the development of patient-derived bioprinted tissue models using controlled fractions of alginate, gelatin, and Matrigel, supporting cancer spheroid growth. These engineered models can be dissociated and reprinted to generate multigenerational models, showing potential for studying patient drug response in vivo.

BIOFABRICATION (2021)

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Review Pharmacology & Pharmacy

Preclinical models and technologies to advance nanovaccine development

Carina Peres et al.

Summary: Targeted immunotherapies have revolutionized cancer treatment, but tumor heterogeneity and immunosuppression mechanisms have hindered the success of cancer vaccines. Nanotechnology offers promising solutions, but the selection of appropriate preclinical models is crucial.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

Cancer-associated fibroblasts: overview, progress, challenges, and directions

Qinrong Ping et al.

Summary: Tumors are a leading cause of death in humans, and developing safe and effective methods for early diagnosis and treatment is crucial. The tumor microenvironment (TME) plays a key role in regulating tumor behavior, with cancer-associated fibroblasts (CAFs) being important regulators. However, the heterogeneity and functions of CAFs present challenges in research and treatment.

CANCER GENE THERAPY (2021)

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Article Materials Science, Biomaterials

Cytotoxic and chemosensitizing effects of glycoalkaloidic extract on 2D and 3D models using RT4 and patient derived xenografts bladder cancer cells

Mariza Abreu Miranda et al.

Summary: The study demonstrated the chemosensitizing effect of glycoalkaloidic extract with cisplatin in treating bladder cancer cells, inhibiting cell growth and migration while inducing apoptosis. The down-regulation of anti-apoptotic proteins and activation of the caspase cascade were observed, suggesting a potential combination therapy strategy for bladder cancer.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity

Min Tang et al.

Summary: This study developed biomimetic tri-regional GBM models to study tumor cell behaviors and angiogenic potentials by mimicking tumor regions, acellular ECM regions, and an endothelial region with different stiffness levels.

SMALL (2021)

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Article Cell Biology

3D-Printed Collagen Scaffolds Promote Maintenance of Cryopreserved Patients-Derived Melanoma Explants

Yun-Mi Jeong et al.

Summary: The study demonstrates that 3D-printed collagen scaffolds can improve the maintenance and survival rate of cryopreserved patient-derived melanoma explants (PDME) compared to traditional 2D culture. These scaffolds retained the expression of melanoma biomarkers in cryopreserved PDME for 21 days.

CELLS (2021)

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Review Pharmacology & Pharmacy

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

Sabina Pozzi et al.

Summary: Three-dimensional cancer models have been developed to study a wide range of biological applications, including cell signaling pathways, metastatic cascade steps, and personalized medicine, in vitro. By combining different cell types and external stimuli, these models can more accurately mimic the biology and pathophysiology of in vivo tumors.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Oncology

Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies

Andrew M. K. Law et al.

Summary: The failure of over 90% of potential anti-cancer drug candidates in clinical trials is mainly attributed to the inaccurate pre-clinical models currently used. Properly modeling the complexity of the tumor microenvironment through 3D culture models can enhance drug discovery and personalized therapies. Technological advancements in this field show promising applications in improving cancer therapeutics.

FRONTIERS IN ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy

Majid Sharifi et al.

Summary: Bioprinting technique enables the study of biological changes in response to pharmacological compounds, specifically in breast cancer tissue for personalized medicine. Challenges in reproducibility of 3D bioprinted breast cancer tissue are mainly due to uncertainty in scaffold materials and lack of printing methods. Future applications of bioprinted cancer models may facilitate rapid and precise drug screening in breast cancer research.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Multidisciplinary Sciences

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

Eilam Yeini et al.

Summary: The study revealed the crucial role of P-selectin in promoting GB proliferation and invasion, showing that inhibiting P-selectin could reduce tumor growth and increase survival in mouse models. The findings shed light on the function of tumor-associated microglia/macrophages and the mechanisms by which GB cells suppress the immune system and invade the brain, paving the way to exploit P-selectin as a target for GB therapy.

NATURE COMMUNICATIONS (2021)

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Article Immunology

3D Bioprinting Allows the Establishment of Long-Term 3D Culture Model for Chronic Lymphocytic Leukemia Cells

Francesca Vittoria Sbrana et al.

Summary: The study introduced the use of three-dimensional bioprinting technology to establish an in vitro model of Chronic Lymphocytic Leukemia (CLL), successfully increasing cell viability in vitro and establishing a long-term 3D culture model. Through RNA sequencing analysis, consistent differences in gene expression profiles between 2D and 3D samples were observed, indicating the potential of this new model to better mimic physiological conditions for cell interactions in vivo.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Christiana M. Neophytou et al.

Summary: The tumor microenvironment (TME) plays a crucial role in cancer progression, influencing tumor aggressiveness, dissemination, and immune evasion. Interactions between cellular and structural TME components enable cancer cells to invade and spread, and the extracellular matrix (ECM) also affects cancer cell migration and therapy response. Current and future strategies aim to target these components to block metastasis.

CANCERS (2021)

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Article Chemistry, Physical

Construction of Tissue-Level Cancer-Vascular Model with High-Precision Position Control via In Situ 3D Cell Printing

Byoung Soo Kim et al.

Summary: During tumor progression, the size and location of the tumor play a significant role in determining its metastatic potential. A novel tissue-level platform using in situ 3D cell printing was presented to study cancer-vascular interactions and investigate metastasis-associated changes. The platform enables precise positioning control and may open new possibilities for precision cancer medicine.

SMALL METHODS (2021)

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Article Biochemistry & Molecular Biology

Establishment of Three-Dimensional Bioprinted Bladder Cancer-on-a-Chip with a Microfluidic System Using Bacillus Calmette-Guerin

Jung Hoon Kim et al.

Summary: The study revealed that the bladder cancer-on-a-chip (BCOC) developed using three-dimensional bioprinting and microfluidic technology can effectively mimic the tumor microenvironment (TME), leading to improved immunotherapeutic effects for bladder cancer by evaluating TME influence and immune responses. The optimal evaluation time for BCOC viability, cytokine concentration, and monocyte migration was found to be 6 hours, 24 hours, and three days post-BCG treatment, respectively. Additionally, the immunotherapeutic effects of BCOC increased with higher dosages of Bacillus Calmette-Guerin (BCG).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

A Covalently Crosslinked Ink for Multimaterials Drop-on-Demand 3D Bioprinting of 3D Cell Cultures

Robert H. Utama et al.

Summary: A new method combining multiple nozzles and fast logic for printing is able to rapidly prepare complex 3D cell culture models with multiple hydrogel environments in a standard 96-well plate format.

MACROMOLECULAR BIOSCIENCE (2021)

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Article Immunology

A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization

Laura Grunewald et al.

Summary: The study shows that in a three-dimensional neuroblastoma model, L1CAM-specific CAR T cell activation by neuroblastoma cells was stronger, but neuroblastoma cell lysis was lower compared to 2D cocultures.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Lena Neufeld et al.

Summary: Current cancer models lack tumor-stroma interactions, affecting the proper representation of cancer's complex biology. By creating bioink with patient-derived cells, tumor heterogenic microenvironment can be recapitulated, leading to similar growth curves, drug response, and genetic signature in 3D models compared to traditional 2D cultures. This 3D-bioprinted model has the potential to replace cell cultures and animal models for rapid and robust target discovery, personalized therapy screening, and drug development.

SCIENCE ADVANCES (2021)

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Article Cell & Tissue Engineering

Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Jungho Back et al.

Summary: Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells leads to increased inflammatory osteolysis and decreased bone formation, increasing the risk of pathological fractures and cancer growth. Osteolytic breast cancers with high pERK1/2 expression disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer interface. Inflammatory osteolysis processes modulate ERK1/2 activation to promote breast cancer growth within bone.

BONE RESEARCH (2021)

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Review Oncology

3D In Vitro Model (R)evolution: Unveiling Tumor-Stroma Interactions

Joao Rodrigues et al.

Summary: Understanding the interactions between cancer cells and their surrounding tissue, known as the tumor microenvironment, is crucial for cancer progression. 3D in vitro models are valuable tools that help bridge the gap between oversimplified 2D systems and unrepresentative animal models in studying tumor-stroma interactions. By focusing on the tumor microenvironment as a key target in cancer therapy, researchers can gain deeper insights into disease progression.

TRENDS IN CANCER (2021)

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Article Medicine, General & Internal

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

Olivier J. Wouters et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Oncology

Applications of patient-derived tumor xenograft models and tumor organoids

Go J. Yoshida

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Engineering, Biomedical

Laser-assisted 3D bioprinting of exocrine pancreas spheroid models for cancer initiation study

Davit Hakobyan et al.

BIOFABRICATION (2020)

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Article Multidisciplinary Sciences

High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment

Mehmet S. Ozturk et al.

SCIENCE ADVANCES (2020)

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Article Cell Biology

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

Min Tang et al.

CELL RESEARCH (2020)

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Article Multidisciplinary Sciences

Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model

W. F. Hynes et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Creation of bladder assembloids mimicking tissue regeneration and cancer

Eunjee Kim et al.

NATURE (2020)

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Article Cell Biology

An Automated Organoid Platform with Inter-organoid Homogeneity and Inter-patient Heterogeneity

Shengwei Jiang et al.

CELL REPORTS MEDICINE (2020)

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Article Materials Science, Biomaterials

3D biofabrication of microfiber-laden minispheroids: a facile 3D cell co-culturing system

Mingjun Xie et al.

BIOMATERIALS SCIENCE (2020)

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Article Engineering, Biomedical

Directly coaxial 3D bioprinting of large-scale vascularized tissue constructs

Lei Shao et al.

BIOFABRICATION (2020)

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Article Medicine, Research & Experimental

3D printed in vitro tumor tissue model of colorectal cancer

Haoxiang Chen et al.

THERANOSTICS (2020)

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Article Engineering, Biomedical

Bioprinting of patient-derivedin vitrointrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing

Shuangshuang Mao et al.

BIOFABRICATION (2020)

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Article Oncology

Exploring Cancer Cell Behavior In Vitro in Three-Dimensional Multicellular Bioprintable Collagen-Based Hydrogels

Daniela F. Duarte Campos et al.

CANCERS (2019)

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Article Engineering, Biomedical

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

Hee-Gyeong Yi et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Article Engineering, Biomedical

An integrated cell printing system for the construction of heterogeneous tissue models

Tian-kun Liu et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair

Xia Cao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Engineering, Biomedical

3D bioprinting of hepatoma cells and application with microfluidics for pharmacodynamic test of Metuzumab

Yang Li et al.

BIOFABRICATION (2019)

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Article Multidisciplinary Sciences

Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks

S. Mishriki et al.

RESEARCH (2019)

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Article Engineering, Biomedical

3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels

Peter A. Mollica et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

Fanben Meng et al.

ADVANCED MATERIALS (2019)

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Article Cell Biology

Tumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks

Sonja K. Schmidt et al.

CELLS (2019)

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Article Engineering, Biomedical

Bioprinting of 3D breast epithelial spheroids for human cancer models

Swathi Swaminathan et al.

BIOFABRICATION (2019)

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Article Engineering, Biomedical

Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells

Jinfu Diao et al.

BIOFABRICATION (2019)

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Article Cell Biology

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Ellen M. Langer et al.

CELL REPORTS (2019)

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Article Engineering, Biomedical

Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies

David M. Kingsley et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics

Marcel Alexander Heinrich et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Bioprinting a novel glioblastoma tumor model using a fibrin-based bioink for drug screening

C. Lee et al.

MATERIALS TODAY CHEMISTRY (2019)

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Review Oncology

Modelling cancer in microfluidic human organs-on-chips

Alexandra Sontheimer-Phelps et al.

NATURE REVIEWS CANCER (2019)

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Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Materials Science, Biomaterials

Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer

Manjulata Singh et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer

Manjulata Singh et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Review Pharmacology & Pharmacy

Drug Repositioning in Glioblastoma: A Pathway Perspective

Sze Kiat Tan et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Engineering, Biomedical

Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture

Xuanyi Ma et al.

BIOMATERIALS (2018)

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Review Genetics & Heredity

Progress and potential in organoid research

Giuliana Rossi et al.

NATURE REVIEWS GENETICS (2018)

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Review Nanoscience & Nanotechnology

Bioresponsive materials

Yue Lu et al.

NATURE REVIEWS MATERIALS (2017)

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Article Oncology

Exploratory analysis of biomarkers associated with clinical outcomes from the study of lenvatinib in differentiated cancer of the thyroid

Makoto Tahara et al.

EUROPEAN JOURNAL OF CANCER (2017)

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Review Materials Science, Multidisciplinary

Tissue engineering by decellularization and 3D bioprinting

Elena Garreta et al.

MATERIALS TODAY (2017)

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Article Genetics & Heredity

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben-David et al.

NATURE GENETICS (2017)

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Article Multidisciplinary Sciences

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

Yuan Tang et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening

Girdhari Rijal et al.

SCIENCE ADVANCES (2017)

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Article Nanoscience & Nanotechnology

3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

Xuan Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Oncology

Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

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Article Chemistry, Physical

Biomimetic 4D printing

A. Sydney Gladman et al.

NATURE MATERIALS (2016)

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Article Engineering, Biomedical

3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility

Xingliang Dai et al.

BIOFABRICATION (2016)

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Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

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Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

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Article Engineering, Biomedical

Three-dimensional printing of Hela cells for cervical tumor model in vitro

Yu Zhao et al.

BIOFABRICATION (2014)

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Article Pharmacology & Pharmacy

Clinical Pharmacogenomics: Opportunities and Challenges at Point of Care

S. A. Scott

CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)

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Editorial Material Oncology

Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy

Pascale Hubert et al.

ONCOIMMUNOLOGY (2012)

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Article Biochemical Research Methods

A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform

Feng Xu et al.

BIOTECHNOLOGY JOURNAL (2011)

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Review Biochemistry & Molecular Biology

The tumor microenvironment and its role in promoting tumor growth

T. L. Whiteside

ONCOGENE (2008)

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Article Hematology

The ability of sorafenib to inhibit oncogenic PDGFR beta and FLT3 mutants and overcome resistance to other small molecule inhibitors

Els Lierman et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2007)

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Inkjet printing of viable mammalian cells

T Xu et al.

BIOMATERIALS (2005)

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Review Pharmacology & Pharmacy

Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

ZM Qian et al.

PHARMACOLOGICAL REVIEWS (2002)

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