期刊
BIOENGINEERING-BASEL
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering9100555
关键词
vascularization; tissue engineering; 3d bioprinting; biomaterials; cardiac engineering; extracellular matrix
资金
- US National Institutes of Health [R01 HL127113, R01 HL142718]
- US Department of Veterans Affairs [1I01BX002310, 1I01BX004259, RX001222]
- National Science Foundation [1829534]
- California Institute for Regenerative Medicine [10603]
- American Heart Association [20IPA35360085, 20IPA35310731]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1829534] Funding Source: National Science Foundation
A major challenge in engineering scalable three-dimensional tissues is the generation of a functional microvascular network. Current biological approaches involve vascular cells, soluble factors, and instructive biomaterials. This review highlights the developments in spatiotemporal control of these biological approaches through angiogenic factors, differentiation of vascular cells, and microfabrication of complex vascular networks.
A major challenge in engineering scalable three-dimensional tissues is the generation of a functional and developed microvascular network for adequate perfusion of oxygen and growth factors. Current biological approaches to creating vascularized tissues include the use of vascular cells, soluble factors, and instructive biomaterials. Angiogenesis and the subsequent generation of a functional vascular bed within engineered tissues has gained attention and is actively being studied through combinations of physical and chemical signals, specifically through the presentation of topographical growth factor signals. The spatiotemporal control of angiogenic signals can generate vascular networks in large and dense engineered tissues. This review highlights the developments and studies in the spatiotemporal control of these biological approaches through the coordinated orchestration of angiogenic factors, differentiation of vascular cells, and microfabrication of complex vascular networks. Fabrication strategies to achieve spatiotemporal control of vascularization involves the incorporation or encapsulation of growth factors, topographical engineering approaches, and 3D bioprinting techniques. In this article, we highlight the vascularization of engineered tissues, with a focus on vascularized cardiac patches that are clinically scalable for myocardial repair. Finally, we discuss the present challenges for successful clinical translation of engineered tissues and biomaterials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据