期刊
BIOENGINEERING-BASEL
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering9100499
关键词
pulsed field ablation; PFA; electroporation; H-FIRE; thermal mitigation; temperature prediction; black-box modeling; agar phantom
资金
- National Institutes of Health/National Cancer Institute [R01 CA240476]
- ICTAS Doctoral Fellowship at Virginia Tech
- P.E.O Scholar Award
A data-driven state-space model was developed to evaluate the feasibility of real-time temperature monitoring during an electroporation-based therapy procedure. The experimental results demonstrated that accurate real-time temperature monitoring can be achieved through real-time impedance monitoring.
To evaluate the feasibility of real-time temperature monitoring during an electroporation-based therapy procedure, a data-driven state-space model was developed. Agar phantoms mimicking low conductivity (LC) and high conductivity (HC) tissues were tested under the influences of high (HV) and low (LV) applied voltages. Real-time changes in impedance, measured by Fourier Analysis SpecTroscopy (FAST) along with the known tissue conductivity and applied voltages, were used to train the model. A theoretical finite element model was used for external validation of the model, producing model fits of 95.8, 88.4, 90.7, and 93.7% at 4 mm and 93.2, 58.9, 90.0, and 90.1% at 10 mm for the HV-HC, LV-LC, HV-LC, and LV-HC groups, respectively. The proposed model suggests that real-time temperature monitoring may be achieved with good accuracy through the use of real-time impedance monitoring.
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