期刊
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
卷 55, 期 -, 页码 -出版社
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0122-2022
关键词
Toxoplasma gondii; ME49 and VEG strains; Rattus norvegicus; Behavior alterations; Arginine-vasopressin promoter gene
This study investigated the behavioral changes in rats infected with different strains of Toxoplasma gondii. It was found that significant differences in the methylation of the arginine-vasopressin promoter gene were observed between rats infected with different strains.
Background: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated.Methods: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, argininevasopressin gene methylation in the central nervous system was evaluated.Results: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains.Conclusions: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains.
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