期刊
NEUROIMAGE-CLINICAL
卷 36, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2022.103227
关键词
Anhedonia; Depression; Bipolar disorder; Schizophrenia; Ventromedial prefrontal cortex; fMRI
类别
Deficits in motivation and pleasure are common in psychiatric disorders, and the dysfunction in the ventromedial prefrontal cortex (vmPFC) is specifically linked to these impairments. These findings provide a potential neural target for the development of novel treatments for amotivation and anhedonia.
Deficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for an association between neural value signals and symptoms of amotivation and anhedonia across adults with major depression, bipolar disorder, schizophrenia, or no psychiatric diagnosis. We found that value signals in the ventromedial prefrontal cortex (vmPFC) during intertemporal decision-making were dampened in individuals with greater motivational and hedonic deficits, after accounting for primary diagnosis. This relationship remained significant while controlling for diagnosis-specific symptoms of mood and psychosis, such as depression as well as positive and negative symptoms. Our results demonstrate that dysfunction in the vmPFC during value-based decision-making is specifically linked to motivational and hedonic impairments. These findings provide a quantitative neural target for the potential development of novel treatments for amotivation and anhedonia.
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