Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim

In this research, detection of trimethoprim (TMP) was carried out using a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) with an anionic surfactant and sodium dodecyl sulphate (SDS) with the help of voltametric techniques. The electrochemical nature of TMP was studied in 0.2 M pH 3.0 phosphate-buffer solution (PBS). The developed electrode displayed the highest peak current compared to nascent CPE. Effects of variation in different parameters, such as pH, immersion time, scan rate, and concentration, were investigated. The electrode process of TMP was irreversible and diffusion controlled with two electrons transferred. The effective concentration range (8.0 x 10(-7) M-1.0 x 10(-5) M) of TMP was obtained by varying the concentration with a lower limit of detection obtained to be 2.58 x 10(-8) M. In addition, this approach was effectively employed in the detection of TMP in pharmaceutical dosages and samples of urine with the excellent recovery data, suggesting the potency of the developed electrode in clinical and pharmaceutical sample analysis.

Automated summary

In this research, a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) was used along with an anionic surfactant and sodium dodecyl sulphate (SDS) to detect trimethoprim (TMP) through voltametric techniques. The electrode showed higher peak current than the original CPE. Various parameters such as pH, immersion time, scan rate, and concentration were studied. The TMP electrode process was found to be irreversible and diffusion controlled with two electrons transferred. The developed electrode proved effective in detecting TMP in pharmaceutical dosages and urine samples, indicating its potential in clinical and pharmaceutical sample analysis.