期刊
CURRENT ISSUES IN MOLECULAR BIOLOGY
卷 44, 期 10, 页码 4447-4471出版社
MDPI
DOI: 10.3390/cimb44100305
关键词
colorectal cancer; angiogenesis; VEGF; NF-kappa B; JAK-STAT; Wnt; Notch
资金
- Natural Science Foundation of China [81572972]
- Supporting Plan of Scientific and Technological Innovation Team in Universities of Henan Province [20IRTSTHN029]
- scientific and technological research project of Henan Province [212102310250]
Although progress has been made in CRC research, CRC still remains the second most frequent type of malignancy and the major cause of cancer-related death among gastrointestinal cancers. Understanding the key signaling pathways that regulate CRC angiogenesis is critical in inhibiting CRC.
Although productive progress has been made in colorectal cancer (CRC) researchs, CRC is the second most frequent type of malignancy and the major cause of cancer-related death among gastrointestinal cancers. As angiogenesis constitutes an important point in the control of CRC progression and metastasis, understanding the key signaling pathways that regulate CRC angiogenesis is critical in elucidating ways to inhibit CRC. Herein, we comprehensively summarized the angiogenesis-related pathways of CRC, including vascular endothelial growth factor (VEGF), nuclear factor-kappa B (NF-kappa B), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Wingless and int-1 (Wnt), and Notch signaling pathways. We divided the factors influencing the specific pathway into promoters and inhibitors. Among these, some drugs or natural compounds that have antiangiogenic effects were emphasized. Furthermore, the interactions of these pathways in angiogenesis were discussed. The current review provides a comprehensive overview of the key signaling pathways that are involved in the angiogenesis of CRC and contributes to the new anti-angiogenic strategies for CRC.
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