期刊
GELS
卷 8, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/gels8100655
关键词
hesperidin; Proteus vulgaris; antibacterial; xanthan gum; gold nanoparticles
This study developed a transdermal nanoformulation for Proteus vulgaris using hesperidin, which showed good drug release and antimicrobial activity. It could be an advanced approach for treating Proteus vulgaris infections.
The objective of the study was to develop a transdermal nanoformulation of hesperidin (HSP) against Proteus vulgaris (P. vulgaris). Based on the low water solubility of HSP, we prepared HSP-enabled AuNPs stabilized with xanthan gum (XA), referred to as HSP@XA@AuNPs. The HSP@XA@AuNP formulation was evaluated for particle size (43.16 nm), PDI (0.565), zeta potential (-31.9 mV), and entrapment efficiency (56.7%). The HSP@XA@AuNPs gel was developed by incorporating selected formulation grades into a 1% Carbopol gel base and characterized by physical evaluation and rheological studies. The color of the HSP@XA@AuNP gel was light pink, and the texture was very smooth and non-greasy. The gel was shown to be odorless. A field emission scanning electron microscope (FESEM) was used to investigate the shape of HSP@XA@AuNPs further. The drug release was 73.08% for the HSP@XA@AuNPs and 86.26% for the HSP@XA@AuNPs gel in 500 min. The prepared gel showed antimicrobial activity against P. vulgaris with an MIC of 1.78 mu g/mL. In conclusion, the HSP@XA@AuNPs gel could be an advanced modality for treating P. vulgaris.
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