期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/4962351
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资金
- National Institutes of Health [DA027550, DA036163, DA022177, DA036413, DA040329]
- National Natural Science Foundation of China [81271334]
- HIV/AIDS Research Award from the Robert Mapplethorpe Foundation
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA040329, R01DA027550, R21DA036163, R03DA036413, R01DA022177] Funding Source: NIH RePORTER
Lipopolysaccharide-(LPS-) mediated systemic inflammation plays a critical role in neurodegenerative diseases. The present study was conducted to evaluate the protective effects of epigallocatechin gallate (EGCG), the major component in green tea, on LPS-mediated inflammation and neurotoxicity. LPS treatment of macrophages induced expression of proinflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6). However, EGCG pretreatment of macrophages significantly inhibited LPS-mediated induction of these cytokines. In addition, EGCG significantly diminished LPS-induced inflammatory cytokines in the peripheral mononuclear blood cells (PBMCs). Supernatant from EGCG-pretreated and LPS-activated macrophage cultures was found to be less cytotoxic to neurons than that from non-EGCG-pretreated and LPS-activated macrophage cultures. Furthermore, EGCG treatment of neurons could inhibit LPS-induced production of reactive oxygen species (ROS). Thus EGCG represents a potent and useful neuroprotective agent for inflammation-mediated neurological disorders.
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