4.5 Article

Real-world efficacy and safety of dolutegravir plus lamivudine versus tenofovir plus lamivudine and efavirenz in ART-naive HIV-1-infected adults

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Dolutegravir plus lamivudine versus efavirenz plus tenofovir disoproxil fumarate and lamivudine in antiretroviral-naive adults with HIV-1 infection

Lisi Deng et al.

Summary: This study evaluated the efficacy and safety of dolutegravir plus lamivudine in ART-naive adults in China. The results showed that DTG + 3TC achieved virologic suppression more rapidly than EFV + TDF + 3TC after 12 and 24 weeks, and there were also significant changes in CD4 cell counts.

BMC INFECTIOUS DISEASES (2022)

Article Medicine, General & Internal

Quantification of Total HIV DNA as a Marker to Measure Viral Reservoir: Methods and Potential Implications for Clinical Practice

Simone Belmonti et al.

Summary: This review examines the importance of quantifying total HIV DNA in targeting the HIV reservoir and discusses the clinical implications and challenges of its future application. Total HIV DNA quantification is the most widely used marker for exploring the HIV reservoir, providing insights into HIV pathogenesis. The clinical role of total HIV DNA in both untreated and treated patients is extensively supported by evidence, and efforts to standardize protocols and involve the biomedical industry are needed to further advance its use in clinical practice.

DIAGNOSTICS (2022)

Article Immunology

Three-year durable efficacy of dolutegravir plus lamivudine in antiretroviral therapy - naive adults with HIV-1 infection

Pedro Cahn et al.

Summary: The study assessed the efficacy and safety of dolutegravir lamivudine compared to dolutegravir with tenofovir disoproxil fumarate/emtricitabine in treatment-naive adults with HIV-1. The results showed that dolutegravir lamivudine was noninferior to dolutegravir with tenofovir disoproxil fumarate/emtricitabine in terms of virologic response. The dolutegravir lamivudine group had a lower rate of adverse events and less impact on renal and bone biomarkers. These findings support the use of dolutegravir lamivudine as a first-line treatment for HIV-1.
Article Pharmacology & Pharmacy

Effectiveness, Durability, and Safety of Dolutegravir and Lamivudine Versus Dolutegravir, Lamivudine, and Abacavir in a Real-Life Cohort of HIV-Infected Adults

Ines Mendoza et al.

Summary: The study did not demonstrate noninferiority in terms of virological effectiveness, but all effectiveness measures supported the use of Dolutegravir plus Lamivudine as an initial and switch option in a real-life cohort of treatment-naive and treatment-experienced patients. Additionally, the durability and safety of 2-DR were confirmed to be similar to that of 3-DR.

ANNALS OF PHARMACOTHERAPY (2022)

Article Immunology

Dolutegravir/lamivudine as a first-line regimen in a test-and-treat setting for newly diagnosed people living with HIV

Charlotte-Paige Rolle et al.

Summary: This study evaluated the feasibility and efficacy of DTG/3TC in a test-and-treat setting. 78% of the 131 participants achieved HIV-1 RNA less than 50 copies/ml at Week 24, with a low incidence of drug-related adverse events.
Review Medicine, General & Internal

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults 2020 Recommendations of the International Antiviral Society-USA Panel

Michael S. Saag et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Immunology

HIV-1 DNA Decay Dynamics in Blood During More Than a Decade of Suppressive Antiretroviral Therapy

Guillaume J. Besson et al.

CLINICAL INFECTIOUS DISEASES (2014)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetic, Pharmacodynamic and Drug-Interaction Profile of the Integrase Inhibitor Dolutegravir

Mackenzie L. Cottrell et al.

CLINICAL PHARMACOKINETICS (2013)