期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 40, 期 1, 页码 63-68出版社
SPRINGER
DOI: 10.1007/s40618-016-0529-2
关键词
Galanin; Obesity; Blood pressure; Hypertension; DBP
资金
- Science and Technology Program of Taizhou, China [TS201512]
- National Health and Family Planning Commission of China [W201309]
- Natural Scientific Fund of the Jiangsu Higher Education Institutions of China [14KJB310012]
- Jiangsu Postgraduate Scientific Research and Innovation Projects [KYLX15_1387]
Background Obesity is strongly linked to increased blood pressure, which increases the risk of cardiovascular diseases. To our knowledge, little literature reported the information about galanin levels in obese individuals with hypertension. Therefore, the aim of this study was to investigate the possible involvement of galanin in the pathogenesis of obese subjects with hypertension. Methods We measured body mass index and blood pressure of 38 obese patients with hypertension, 44 obese controls with normal blood pressure and 44 lean controls with normal blood pressure. Blood samples from all cases were collected at 8:00 a.m. after an overnight fast to determine the fasting plasma concentration of galanin, glucose, insulin, triglyceride, total cholesterol, high- and low-density lipoprotein cholesterol. Results We found that plasma galanin levels were significantly decreased in obese patients with hypertension compared with the obese control group, whereas the galanin levels were significantly increased in obese controls compared with lean controls. Furthermore, in both obese groups the galanin levels were negatively correlative to diastolic blood pressure and positively correlative to insulin and triglyceride levels, but not to heart rate. Conclusion Low galanin levels were one of characters of obese patients with high blood pressure, and this levels may be taken as a novel biomarker to predict the development of high blood pressure in obese patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据