期刊
NEOPLASMA
卷 69, 期 5, 页码 1175-1184出版社
AEPRESS SRO
DOI: 10.4149/neo_2022_220228N218
关键词
SNHG9; miR-214-5p; SOX4; feedback loop; osteosarcoma
类别
In osteosarcoma, the overexpression of SNHG9 is closely associated with cell proliferation, migration, and invasion abilities. SNHG9 interacts with miR-214-5p and SOX4, forming an important feedback loop involved in the progression of osteosarcoma.
Osteosarcoma (OS) is a high-grade, aggressive bone sarcoma. LncRNAs play a key regulatory role in controlling biological and pathological processes. The expression of lncRNA SNHG9 varies among different cancer tissues, and the role of SNHG9 in OS progression is unclear. In this study, we found SNHG9 overexpression in OS tissues and cells. In addition, downregu-lated SNHG9 expression impaired the proliferation, migration, and invasion abilities of OS cells. SNHG9 expression was positively regulated by the transcription factor SOX4. SNHG9 interacted with miR-214-5p as a molecular sponge and SOX4 was identified as the target of miR-214-5p. The interaction affected the expression of SNHG9, miR-214-5p, and SOX4, and regulated OS cell proliferation, migration, and invasion. Therefore, the SNHG9/miR-214-5p/SOX4 feedback loop performs an important role in OS progression and might be used as a new potential therapeutic target for the treatment of OS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据