期刊
NEUROIMAGE-CLINICAL
卷 36, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2022.103235
关键词
Sleep -disordered breathing; Entorhinal cortex; Hippocampus; Sex differences; Mild cognitive impairment
类别
资金
- Canadian Institutes of Health Research [FDN154291, MOP123294, MOP102631, PJT153259]
- Fonds de la Recherche du Que'bec - Sante'
- Quebec Bio-Imaging Network
The study found that the association between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes is influenced by sex, age, cognitive status, and free-water fraction correction. Further research is needed to investigate whether the increase in medial temporal subregion volumes leads to neuronal death in untreated OSA patients.
Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer's disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55-86 years (35 % women). We also investigated the impact of sex, age, cognitive status, and free-water fraction correction on these associations. Increased OSA severity was associated with larger hippocampal and entorhinal cortex volumes in women, but not in men. Greater OSA severity also correlated with increased hippocampal volumes in participants with amnestic mild cognitive impairment, but not in cognitively unimpaired participants, regardless of sex. Using free-water corrected volumes eliminated all significant associations with OSA severity. Therefore, the increase in medial temporal subregion volumes may possibly be due to edema. Whether these structural manifestations further progress to neuronal death in non-treated OSA patients should be investigated.
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