4.5 Article

Clinical Features in Parkinson's Disease Patients with Hyperechogenicity in Substantia Nigra: A Cross-Sectional Study

期刊

NEUROPSYCHIATRIC DISEASE AND TREATMENT
卷 18, 期 -, 页码 1593-1601

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S374370

关键词

Parkinson?s disease; transcranial sonography; substantia nigra hyperechogenicity; non -motor symptoms; gait analysis

资金

  1. National Natural Science Foundation of China [82171249]
  2. Jiangsu Provincial Cadre Health Projects [BJ20005]
  3. Special Funds of the Jiangsu Provincial Key Research and Development Program [BE2019612]
  4. Jiangsu Province Elderly Health Project [LD2021013]
  5. Nanjng Medical University School Fund Project [NMUB20210223]
  6. Nanjing Medical Science and Technology Development Foundation [QRX17026]
  7. Nanjing Rehabilitation Medicine Center Project

向作者/读者索取更多资源

This study aimed to explore the relationship between substantia nigra hyperechogenicity (SNH) and the clinical features of Parkinson's disease (PD). The results showed that SNH was significantly correlated with activities of daily living and gait impairment in Chinese patients with PD, suggesting the formation of SNH might be a dynamic biomarker reflecting disease severity.
Background: Transcranial ultrasound (TCS) can be used to reveal structural changes in the substantia nigra (SN) and is a potential tool for the early diagnosis of Parkinson's disease (PD). This study aimed to explore the relationship between substantia nigra hyperechogenicity (SNH) and the clinical features of PD patients.Methods: A total of 96 PD patients were included in our study. All patients were detected by TCS and divided into two groups: PD patients with SNH (PDSN+) and those with normal SN echogenicity (PDSN-). The Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn & Yahr stage were used to assess the extent of disease-related disability of the PD patients. Non-motor symptoms were evaluated by using several scales. The instrumented stand and walk test was performed on all subjects, and gait data were gathered using a JiBuEn gait analysis system.Results: Seventy-five PD patients were successfully assessed by TCS. We found that SNH was associated with a higher UPDRS II scores (p = 0.028). In addition, compared with PDSN-group, the PDSN+ group exhibited more severe gait impairment, including increased variability in stride length (p = 0.042), decreased heel strike angle (p = 0.017), decreased range of motion of hip joints (p = 0.031), and a more asymmetrical walking pattern (p = 0.028).Conclusion: Our study demonstrated that SNH significantly correlated with activities of daily living and gait impairment in Chinese patients with PD, suggesting the formation of SNH might be a dynamic biomarker reflecting disease severity.

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