Management of Lung Cancer Presenting with Solitary Bone Metastasis

Lung neoplasm is the main cause of cancer-related mortality, and bone metastasis is among the most common secondary tumors. The vast majority of patients also present with multiple bone metastases, which makes systemic and adjuvant pain therapy preferable to surgery. The optimal approach for a resectable non-small-cell lung tumor that also presents a unique, resectable bone metastasis is not fully established. The number of papers addressing this subject is small, and most are case reports; nevertheless, survival rates seem to increase with radical surgery. The sequencing of local versus systemic treatment should always be discussed within the multidisciplinary team that will choose the best approach for each patient. As targeted systemic therapies become more accessible, radical surgery, together with existing reconstructive methods, will lead to an increase in life expectancy and a better quality of life.

Automated summary

Lung neoplasm is a leading cause of cancer-related deaths, with bone metastasis being one of the most common secondary tumors. Most patients have multiple bone metastases, making non-surgical systemic and adjuvant pain therapy preferable. The optimal approach for resectable non-small-cell lung tumors with resectable bone metastases remains uncertain. Although few papers have addressed this subject, survival rates appear to increase with radical surgery. The sequencing of local and systemic treatment should be discussed by a multidisciplinary team to determine the best approach for each patient. As targeted systemic therapies become more accessible, radical surgery and existing reconstructive methods will improve life expectancy and quality of life.