4.6 Article

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition

Connor Finkbeiner et al.

Summary: This study combines single-cell transcriptomic analysis with chromatin sequencing to investigate human fetal retinal development and identify key transcription factors and their cascades. By comparing retinal organoids, differences in signaling pathways and gene regulation are discovered. These findings are crucial for improving retinal organoid technology and advancing regenerative medicine approaches for retinal diseases.

CELL REPORTS (2022)

Article Cell & Tissue Engineering

Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model

Kathleen R. Chirco et al.

Summary: The study established a reliable in vitro model for studying gene-editing therapies in Leber congenital amaurosis caused by mutations in CRX. Using allele-specific CRISPR/Cas9-based gene editing, the researchers knocked out mutant CRX and observed moderate rescue of photoreceptor phenotypes in organoids, providing early evidence for an effective approach to treat LCA7.

STEM CELL REPORTS (2021)

Article Developmental Biology

Development and maintenance of vision's first synapse

Courtney A. Burger et al.

Summary: Synapses in the outer retina are crucial for vision, serving as the first relay points for information. The large and ordered nature of these synapses makes them a valuable system for studying synaptic specificity and maintenance mechanisms. Understanding the development, maintenance, and connectivity of these synapses is essential for restoring visual function.

DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

Xueqing Chen et al.

Summary: Notch signaling plays a crucial role in repressing the formation of restricted progenitor cells and maintaining proliferation potential of multipotent retinal progenitor cells, ultimately regulating cone photoreceptor genesis. This mechanism does not involve direct cell cycle promotion but rather indirect effects on progenitor cell state transitions leading to multipotent progenitor cell depletion.

SCIENTIFIC REPORTS (2021)

Article Biochemical Research Methods

BEAVR: a browser-based tool for the exploration and visualization of RNA-seq data

Pirunthan Perampalam et al.

BMC BIOINFORMATICS (2020)

Article Developmental Biology

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation

Michael L. Kaufman et al.

DEVELOPMENTAL BIOLOGY (2019)

Article Multidisciplinary Sciences

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

Marcela Garita-Hernandez et al.

NATURE COMMUNICATIONS (2019)

Article Ophthalmology

Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors

Diego F. Buenaventura et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

Article Multidisciplinary Sciences

The Notch inhibitor cowanin accelerates nicastrin degradation

Midori A. Arai et al.

SCIENTIFIC REPORTS (2018)

Article Genetics & Heredity

CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites

Philip A. Ruzycki et al.

EPIGENETICS & CHROMATIN (2018)

Article Multidisciplinary Sciences

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

Kiara C. Eldred et al.

SCIENCE (2018)

Article Cell Biology

Molecular Anatomy of the Developing Human Retina

Akina Hoshino et al.

DEVELOPMENTAL CELL (2017)

Article Multidisciplinary Sciences

Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration

Hiroshi Shirai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Neurosciences

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Jimmy de Melo et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Anatomy & Morphology

Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease

Henrik Boije et al.

FRONTIERS IN NEUROANATOMY (2016)

Article Anatomy & Morphology

Untitled

DEVELOPMENTAL DYNAMICS (2016)

Article Biochemistry & Molecular Biology

Untitled

JOURNAL OF NEUROCHEMISTRY (2016)

Review Developmental Biology

Photoreceptor cell fate specification in vertebrates

Joseph A. Brzezinski et al.

DEVELOPMENT (2015)

Editorial Material Cell Biology

The role of Islet-1 in cell specification, differentiation, and maintenance of phenotypes in the vertebrate neural retina

Gervasio Martin-Partido et al.

NEURAL REGENERATION RESEARCH (2015)

Article Multidisciplinary Sciences

A platform for rapid generation of single and multiplexed reporters in human iPSC lines

Ying Pei et al.

SCIENTIFIC REPORTS (2015)

Review Neurosciences

Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages

Henrik Boije et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

Review Neurosciences

Intrinsically different retinal progenitor cells produce specific types of progeny

Connie Cepko

NATURE REVIEWS NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development

Darshan Sapkota et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Biochemistry & Molecular Biology

Intrinsic control of mammalian retinogenesis

Mengqing Xiang

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Developmental Biology

Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate

Karolina Mizeracka et al.

DEVELOPMENT (2013)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Ophthalmology

Pax6: A multi-level regulator of ocular development

Ohad Shaham et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2012)

Review Neurosciences

Cell fate determination in the vertebrate retina

Erin A. Bassett et al.

TRENDS IN NEUROSCIENCES (2012)

Article Biotechnology & Applied Microbiology

Differential expression analysis for sequence count data

Simon Anders et al.

GENOME BIOLOGY (2010)

Article Developmental Biology

Vsx2 in the zebrafish retina: restricted lineages through derepression

Marta Vitorino et al.

NEURAL DEVELOPMENT (2009)

Article Developmental Biology

Notch signaling regulates regeneration in the avian retina

Susan Hayes et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Neurosciences

Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells

Yasser Elshatory et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Developmental Biology

Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells

Branden R. Nelson et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Oncology

Recoverin as a cancer-retina antigen

Alexandr V. Bazhin et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2007)

Article Multidisciplinary Sciences

Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property

Ashutosh P. Jadhav et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Efficient generation of retinal progenitor cells from human embryonic stem cells

Deepak A. Lamba et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Developmental Biology

Molecular characterization of retinal stem cells and their niches in adult zebrafish

Pamela A. Raymond et al.

BMC DEVELOPMENTAL BIOLOGY (2006)

Article Multidisciplinary Sciences

Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina

I Livne-Bar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors

M Akimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Cell Biology

Notch signalling: a simple pathway becomes complex

Sarah J. Bray

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Ophthalmology

Expression of photoreceptor-specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retina

KMB O'Brien et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2004)

Article Physiology

Recoverin regulates light-dependent phosphodiesterasc activity in retinal rods

CL Makino et al.

JOURNAL OF GENERAL PHYSIOLOGY (2004)

Article Genetics & Heredity

Nrl is required for rod photoreceptor development

AJ Mears et al.

NATURE GENETICS (2001)

Article Biochemistry & Molecular Biology

Pax6 is required for the multipotent state of retinal progenitor cells

T Marquardt et al.