Application of Bio-Profiles of Chemical Reactions for Analysis of Solvent Impact on Overall Toxicity of C-C Cross-Coupling Process

In this work, we used a recently proposed concept of bio-Profiles and bio-Factors for studying the solvent contribution into the overall cytotoxicity of chemical reactions by the example of synthesis of 1,1'-biphenyl from aryl halide and phenylboronic acid. Two standard solvents (ethanol and N-methylpyrrolidone) and four ionic liquids (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, and cholinium bis(trifluoromethylsulfonyl)imide) were analyzed.

Automated summary

This work investigates the contribution of different solvents to the overall cytotoxicity of chemical reactions using bio-Profiles and bio-Factors, with the synthesis of 1,1'-biphenyl as an example. The analyzed solvents include ethanol, N-methylpyrrolidone, and four ionic liquids.