Synthesis, structure and antibacterial properties of a mononuclear Ag(I) complex, [Ag(OBz)(PTA)2] (OBz = benzoate, PTA = 1, 3, 5-triaza-7-phospadamantane)

A new silver complex, namely [Ag(OBz)(PTA)(2)] (where OBz = benzoate and PTA = 1, 3, 5-triazaphospadamantane) has been synthesized and structurally characterized. The silver center resides in a triangular coordination environment, noticeably deviated from the plane defined by three ligands. [Ag(OBz)(PTA)(2)] has excellent aqueous solubility and also moderate solubility in organic media. Antibacterial studies indicated the effectiveness of this complex towards growth inhibition of three nosocomial pathogens, namely, B. cereus, S. aureus and P aeruginosa. The MIC and IC50 values clearly suggested that the complex induced more significant antibacterial activity against the Gram (+) strains compared to the Gram (-) variety.

Automated summary

A new silver complex with excellent aqueous solubility and moderate solubility in organic media has been synthesized and characterized. The complex demonstrated pronounced antibacterial activity against nosocomial pathogens, particularly Gram (+) strains.