☆ 4.5 Review

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

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Article Engineering, Biomedical

ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

Lulu Jin et al.

Summary: Ischemic stroke is a serious cerebral vascular disease. The polarization of microglia, an important immune component in the central nervous system, is closely related to high mobility group box 1 (HMGB1). By designing reactive oxygen species (ROS) responsive polymer-drug conjugate nanoparticles, it is possible to manipulate microglia polarization and achieve excellent therapeutic efficacy in ischemic stroke treatment.

BIOACTIVE MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Peptide-Modified Nano-Bioactive Glass for Targeted Immobilization of Native VEGF

Matthias Schumacher et al.

Summary: The slow and disorganized formation of a functional vascular network in large bone defect regeneration can cause delayed healing or implant failure. This study introduces a promising strategy by immobilizing the pro-angiogenic growth factor VEGF on nanosized bioactive glass particles using a binding peptide, which can induce angiogenesis and overcome the problem of insufficient neovascularization.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Polymer Science

Shear-thinning hydrogels containing reactive oxygen species-responsive nanoparticles for salvianolic acid B delivery to rescue oxidative damaged HUVECs

Hsin-Ho Chen et al.

Summary: In this study, a laponite hydrogel containing ROS-responsive dextran-based nanoparticles was developed as a carrier for salvianolic acid B (SAB) delivery. The system exhibited good biocompatibility and sustained drug release properties, and was able to scavenge ROS and rescue cells from oxidative damage.

EUROPEAN POLYMER JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Cooperation between Angiogenesis, Vasculogenesis, Chemotaxis, and Coagulation in Breast Cancer Metastases Development: Pathophysiological Point of View

Elzbieta Zarychta et al.

Summary: This article summarizes the roles of angiogenesis, chemotaxis, and coagulation in the development of distant metastases in breast cancer. It highlights that breast cancer is still one of the main causes of morbidity and mortality in women worldwide, but the number of deaths has decreased due to improved diagnostic and therapeutic opportunities. However, metastatic disease remains a therapeutic challenge.

BIOMEDICINES (2022)

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Review Medicine, Research & Experimental

Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives

Rubiya Khursheed et al.

Summary: The advancements in nanotechnology have led to extensive exploration of metallic nanoparticles for biomedical applications. These nanoparticles possess inert nature and nanoscale structures similar to biological molecules, and their characteristics can be altered by changing certain particle properties. They have found applications in targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, and modulation of multiple applications in biomedicine.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Biochemistry & Molecular Biology

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wen-Chin Ko et al.

Summary: Gold is considered a symbol of nobility and its properties make it attractive for a wide range of applications. Gold nanoparticles, with their unique size-dependent properties, have shown potential in biomedical testing, disease diagnosis, and gene detection. The use of gold nanoparticles in targeting cancer cells and their antioxidant and anti-inflammatory effects have been widely studied and show promise in various diseases.

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Sodium butyrate-loaded nanoparticles coated with chitosan for the treatment of neovascularization in age-related macular degeneration: Ocular biocompatibility and antiangiogenic activity

Julia Stephania Dos Reis et al.

Summary: The study found that sodium butyrate-loaded nanoparticles coated chitosan had a diameter of approximately 311.1 nm, a polydispersity index of 0.208, and a zeta potential of +56.3 mV; they were nontoxic to human retinal pigment epithelium cells, did not interfere with the integrity of rat's eye retinal layers, and inhibited angiogenesis in the chorioallantoic membrane assay.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Preparation, physicochemical, and retinal anti-angiogenic evaluation of poloxamer hydrogel containing dexamethasone/avastin-loaded chitosan-N-acetyl-L-cysteine nanoparticles

Sayed Latif Taheri et al.

Summary: This study describes a new drug delivery method using CNAC nanoparticles and Poloxamer hydrogel to enhance the intravitreal administration of Avastin for the treatment of Diabetic retinopathy. The optimized formulation showed improved therapeutic efficacy of Avastin and reduced the frequency, danger, and cost of intravitreal injections.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Materials Science, Multidisciplinary

Effect of polyvinyl alcohol concentration on biomedical application of chitosan/bioactive glass composite coated on AZ91D magnesium alloy

Ehsan Vafa et al.

Summary: The aim of this study is to improve the biomedical properties of AZ91D magnesium by coating it with polyvinyl alcohol (PVA), bioactive glass (BG), and natural chitosan (CH) using the electrophoretic deposition (EPD) method. The results showed that the composite with 25% PVA had higher corrosion resistance and bioactivity.

MATERIALS CHEMISTRY AND PHYSICS (2022)

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Article Multidisciplinary Sciences

Nanoparticle coatings for controlled release of quercetin from an angioplasty balloon

Ioana Craciun et al.

Summary: This study aimed to design a novel drug-coated balloon using a polymeric nanodelivery system for sustained release of polyphenols to reduce restenosis in patients with peripheral artery disease (PAD) after balloon angioplasty. The results showed that the nanoparticle system with quercetin covalently attached had the highest sustained release and anti-proliferative effect, while maintaining adhesion even under calcification conditions. Additionally, the ultrasound coating method produced a uniform balloon coating.

PLOS ONE (2022)

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Article Cell & Tissue Engineering

Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

Qianju Wu et al.

Summary: This study aimed to fabricate bioactive scaffolds by incorporating strontium into modified amino-functional mesoporous bioactive glass (MBG) and investigate their bioactivity in vitro and in vivo. The results showed that the strontium-incorporated scaffolds had good biocompatibility and enhanced osteogenic and angiogenic capacities. In addition, bioinformatics analysis suggested that the scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model, playing an anti-osteoporosis role while promoting osteogenesis.

BONE RESEARCH (2022)

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Review Materials Science, Biomaterials

Molybdenum disulfide (MoS2)-based nanostructures for tissue engineering applications: prospects and challenges

Anuj Kumar et al.

Summary: This article reviews the structural properties of MoS2 nanostructures and their interactions with biological systems, as well as their utility and prospects in tissue engineering applications.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Biology

Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke

Sara Bernardo-Castro et al.

Summary: Stroke is the second leading cause of mortality and morbidity worldwide, with ischemic strokes being the most prevalent type. Current stroke treatment relies heavily on recanalization therapies, but the narrow therapeutic window limits their effectiveness, calling for new treatment options. Nanotechnology holds great promise in stroke treatment by overcoming the blood-brain barrier and targeting different repair mechanisms in each phase of stroke.

LIFE-BASEL (2021)

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Review Health Care Sciences & Services

Targeted Drug Delivery - From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

Ashagrachew Tewabe et al.

Summary: Nanomedicine is an advanced concept that uses targeted drug delivery systems to deliver drugs directly to specific areas in the body, reducing the amount of drug needed for treatment and overcoming the toxic effects of traditional drug delivery. This field involves various carrier systems, such as colloidal and multiparticulate carriers, polymers, and cellular/subcellular systems.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2021)

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Review Materials Science, Multidisciplinary

Materials roles for promoting angiogenesis in tissue regeneration

Jung-Hwan Lee et al.

Summary: This article discusses the importance of proangiogenic efforts in tissue repair and regeneration, focusing on the pivotal roles of engineered matrices in stimulating angiogenesis processes. The design and tuning of matrices for the proper presentation of growth factors and the sustained release of angiogenic molecules are crucial for tissue repair therapies.

PROGRESS IN MATERIALS SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Treatment of Rheumatoid Arthritis by Serum Albumin Nanoparticles Coated with Mannose to Target Neutrophils

Jiayao Lyu et al.

Summary: This study successfully loaded methotrexate (MTX) into nanoparticles of human serum albumin modified with mannose for targeted drug delivery to neutrophils, reducing toxicity and showing significant anti-inflammatory, antiangiogenic, and anti-arthritic effects in experimental models. The nanoparticles prolonged the in vivo circulation of MTX and accumulated mainly in arthritic joints, indicating their potential as a useful drug delivery system for rheumatoid arthritis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

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Review Engineering, Biomedical

Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Yiming Niu et al.

Summary: The coordinated interaction between osteogenesis and the osteoimmune microenvironment is crucial for successful bone healing. Macrophages, as highly plastic cells, play a central regulatory role in bone repair by mediating host immune response and exerting regenerative potency based on the signals they sense. Various engineering strategies are being developed to recruit, activate, and modulate the phenotype transition of macrophages to enhance the performance of engineered bone tissue.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Therapeutic angiogenesis using zinc oxide nanoflowers for the treatment of hind limb ischemia in a rat model

Ayan Kumar Barui et al.

Summary: Critical limb ischemia (CLI) is a severe form of peripheral artery disease (PAD) that results in inadequate blood supply to limb extremities, causing severe pain, impaired wound healing, cardiovascular complications, and potentially leading to amputation or death. Current conventional therapies, such as surgical revascularization and growth factor therapy, have limitations in treating CLI. Developing new alternative therapeutic biomaterials, such as zinc oxide nanoflowers (ZONFs), shows promising potential for inducing therapeutic angiogenesis and treating CLI.

BIOMEDICAL MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Wenxian Du et al.

Summary: Inorganic nanomaterials have great potential in the field of biomedicine, offering new ways to improve the diagnosis and treatment of brain diseases. By surface modification and combining with functional materials, these materials can enhance imaging accuracy and targeting for better outcomes.

MOLECULES (2021)

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Article Chemistry, Applied

Electrophoretic deposition of polyvinyl alcohol/natural chitosan/bioactive glass composite coatings on 316L stainless steel for biomedical application

Ehsan Vafa et al.

Summary: In this study, a polyvinyl alcohol reinforced natural chitosan/bioactive glass composite coating was prepared on 316L stainless steel by electrophoretic deposition process. The 25% PVA concentration in the composite coating showed increased corrosion resistance and bio-stability compared to 15% and 20% PVA concentrations, with better bioactivity and hydroxyapatite forming ability in vitro observed with 20% PVA concentration.

PROGRESS IN ORGANIC COATINGS (2021)

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Review Physiology

The Normal and Brain Tumor Vasculature: Morphological and Functional Characteristics and Therapeutic Targeting

Joris Guyon et al.

Summary: Glioblastoma is a common malignant tumor in the central nervous system with limited treatment options. Blood vessels in the brain play crucial roles, not only in healthy tissue for oxygen and nutrient delivery, but also in tumor microenvironment interacting with other cells. Current research focuses on in vitro engineered artificial blood vessels and the application of anti-angiogenic therapy in glioblastoma treatment.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Advances in Engineering Human Tissue Models

Chrysanthi-Maria Moysidou et al.

Summary: Research in cell biology heavily relies on in vitro assays and models, with the recent advancement in 3D cell biology and engineering providing more physiologically relevant culture platforms. These platforms, such as scaffold-based systems and organs-on-chips, show great potential in bridging the gap between conventional animal studies and human physiology by allowing for more accurate modeling of specific processes.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Bilirubin Nanoparticles Protect Against Cardiac Ischemia/Reperfusion Injury in Mice

Wen Ai et al.

Summary: The study demonstrates that bilirubin nanoparticles (BRNPs) have significant therapeutic effects on myocardial ischemia/reperfusion (I/R) injury, improving cardiac output, reducing myocardial infarct size, and decreasing levels of reactive oxygen species and proinflammatory factors.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Pharmacology & Pharmacy

Investigation of Angiogenesis and Wound Healing Potential Mechanisms of Zinc Oxide Nanorods

Amr Hassan et al.

Summary: This study fabricated green zinc oxide nanorods using albumin eggshell as a bio-template and investigated its angiogenic potential through experiments. The results demonstrated that zinc oxide nanorods induce angiogenesis through mechanisms such as inducing VEGF expression, providing a new approach for developing materials for wound healing.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Food Science & Technology

Bovine serum albumin protected gold nanozymes as a novel anti-cancer nanodrug for acute T-type lymphoblastic leukemia treatment via effect on the expression of anti-apoptotic genes

Ehsan Vafa et al.

Summary: The study indicates that BSA-Au nanozymes can be a potential nanodrug for treating T-type lymphoblastic leukemia by reducing the expression of anti-apoptotic genes, enhancing the effects of common anticancer drugs, and improving patient survival rates.

APPLIED BIOLOGICAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Anti-Angiogenic Therapy: Current Challenges and Future Perspectives

Filipa Lopes-Coelho et al.

Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell & Tissue Engineering

Three dimensional printed nanostructure biomaterials for bone tissue engineering

Tesfa Marew et al.

Summary: The suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Bone tissue engineering has emerged as an alternative for fracture repair, offering the possibility to induce new functional bone regeneration using a synergistic combination of functional biomaterials, cells, and growth factors.

REGENERATIVE THERAPY (2021)

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Article Chemistry, Multidisciplinary

Oxygen-Generating Cyanobacteria Powered by Upconversion-Nanoparticles-Converted Near-Infrared Light for Ischemic Stroke Treatment

Jian Wang et al.

Summary: The study introduces a novel approach to stroke treatment by utilizing a nanotechnology-driven biosystem that generates oxygen through photosynthesis, rescuing neurons and treating stroke effectively. This innovative method combines microorganisms and nanotechnology to improve neuronal function recovery in stroke patients, showing promising results in cell-biological, biochemical, and animal-level behavioral data.

NANO LETTERS (2021)

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Review Engineering, Biomedical

Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Ozlem Sen et al.

Summary: This review examines the use of nanomaterials in the detection and treatment of cancer metastasis, focusing on the impact of nanostructures on cell migration, invasion, and angiogenesis in the tumor microenvironment.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Oncology

Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer

Fatema Tuz Zahra et al.

Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

Hui Zu et al.

Summary: Although non-viral vectors in gene therapy have low cytotoxicity and immunogenicity, they still face challenges in gene transfer efficiency, specificity, gene expression duration, and safety. Overcoming these obstacles is necessary to enhance the effectiveness of non-viral vectors in gene therapy.

AAPS JOURNAL (2021)

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Article Engineering, Environmental

Novel angiogenic metal nanoparticles controlling intracellular gene activation in stem cells

Gwang-Bum Im et al.

Summary: Cu-AMNs have advantages in cell treatment such as low mitochondrial damage, reduced ATP consumption, decreased cytotoxicity, mild reactive oxygen species generation, enhanced angiogenic paracrine factor secretion, and improved HIF1 alpha expression. The transplantation of Cu-AMN-treated hADSCs led to a significant increase in angiogenesis and blood perfusion in a mouse hindlimb ischemia model compared with conventional hADSC therapy.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Dual Stem Cell Therapy Improves the Myocardial Recovery Post-Infarction through Reciprocal Modulation of Cell Functions

Sinziana Popescu et al.

Summary: The study showed that using a dual-cell approach with ECFC and MSC can enhance the therapeutic effects for infarcted hearts, improving heart function and angiogenic properties. In vitro experiments demonstrated that ECFC can enhance MSC effector properties, while MSC can help organize ECFC into vascular networks.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Multidisciplinary

Bio-acceptable 0D and 1D ZnO nanostructures for cancer diagnostics and treatment

Brandon Ortiz-Casas et al.

Materials Today (2021)

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Review Biochemistry & Molecular Biology

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

Bianca Elena-Beatrice Cretu et al.

Summary: Over the past decade, the challenge in nanomedicine imaging has been to design multifunctional agents that can be detected through various techniques. Iron oxide nanoparticles have gained attention due to their magnetic properties, large surface area, and potential for use in different imaging modalities. Nanoparticles based on tracers offer promise for non-invasive, high-resolution imaging with synergistic advantages.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study

Hadi Samadian et al.

Summary: The study aimed to fabricate a 3D scaffold based on PLLA/PCL matrix polymer with GNFs and AuNPs, showing suitable properties for bone tissue engineering, including appropriate porosity, pore size, mechanical properties, biocompatibility, and osteoconduction activities. In vitro studies indicated that 80 ppm AuNPs had the highest cell proliferation, while in vivo studies demonstrated that PCL/PLLA/Gel/80ppmAuNPs scaffold induced the highest neo-bone formation and angiogenesis.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

pH-Sensitive, Cerebral Vasculature-Targeting Hydroxyethyl Starch Functionalized Nanoparticles for Improved Angiogenesis and Neurological Function Recovery in Ischemic Stroke

Hang Yang et al.

Summary: This study introduces a dual-targeted therapeutic strategy for improving drug delivery in ischemic brain, utilizing PHSRN peptides for targeted delivery and SAG@PHSRN-HES nanoparticles to release more SAG in the acidic environment of ischemic brain tissue. The synergistic mechanisms of PHSRN and SAG hold promise in promoting angiogenesis and improving neurological function recovery, suggesting potential for treating cerebral infarction patients.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Cardiac & Cardiovascular Systems

Nanoparticle-Mediated Simultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates Myocardial Ischemia-Reperfusion Injury

Gentaro Ikeda et al.

Summary: The study showed that dual deficiency of CypD and C-C chemokine receptor 2 enhanced cardioprotection during myocardial IR injury. Deletion of C-C chemokine receptor 2 decreased monocyte recruitment, whereas deletion of CypD reduced it with interleukin-1 beta blocking antibody. Combined administration of nanoparticles targeting mitochondrial injury and inflammation improved cardioprotection compared to single administration.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Review Health Care Sciences & Services

The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application

Jun Wu

Summary: Chemotherapy for human solid tumors faces challenges in delivering anticancer compounds selectively into tumor tissues to maintain effective concentration levels for a certain duration, hindering the execution of anticancer activities. Targeting therapy via the enhanced permeability and retention effect may not always be successful, as it depends on tumor type, location, blood perfusion status, and properties of macromolecular anticancer agents. Efforts to maximize the EPR effect in developing smarter nanomedicines are essential for successful clinical applications.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Pharmacology & Pharmacy

Europium Hydroxide Nanorods Mitigate Hind Limb Ischemia in Wistar Rats

Susheel Kumar Nethi et al.

Summary: The study group has developed europium hydroxide nanorods (EHN) which show potential proangiogenic properties, suggesting they may be useful in the treatment of critical limb ischemia. Research has demonstrated that EHN can ameliorate myocardial ischemia and mitigate cadmium-induced vascular toxicity in Wistar rats. Toxicity and pharmacokinetic studies in mice have shown that EHN is non-toxic, indicating the feasibility of their practical clinical application for CLI treatment.

ADVANCED THERAPEUTICS (2021)

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Review Biochemistry & Molecular Biology

Tumor angiogenesis: causes, consequences, challenges and opportunities

Roberta Lugano et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Medicine, General & Internal

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Raluca Ioana Teleanu et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Critical Care Medicine

Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia

Craig Bolte et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Review Cell Biology

Tumor microenvironment complexity and therapeutic implications at a glance

Roghayyeh Baghba et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Review Nanoscience & Nanotechnology

Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases

Rajasekharreddy Pala et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Endosome-triggered ion-releasing nanoparticles as therapeutics to enhance the angiogenic efficacy of human mesenchymal stem cells

Gwang-Bum Im et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Nanoparticles and Their Targeted Delivery Applications

Abuzer Alp Yetisgin et al.

MOLECULES (2020)

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Review Oncology

Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

Harman Saman et al.

CANCERS (2020)

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Article Engineering, Biomedical

Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis

In-Su Park et al.

BIOMATERIALS (2020)

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Review Cell Biology

Motivating role of type H vessels in bone regeneration

Jiankang Zhang et al.

CELL PROLIFERATION (2020)

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Article Pharmacology & Pharmacy

Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration

Priyanka Bhatt et al.

AAPS PHARMSCITECH (2020)

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Article Chemistry, Multidisciplinary

Mitochondria-Inspired Nanoparticles with Microenvironment-Adapting Capacities for On-Demand Drug Delivery after lschemic Injury

Yanxia Lin et al.

ACS NANO (2020)

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Article Medicine, General & Internal

Stroke

Bruce C V Campbell et al.

LANCET (2020)

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Article Polymer Science

Effects of bilayer nanofibrillar scaffolds containing epidermal growth factor onfull-thicknesswound healing

Ali Golchin et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2020)

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Review Biochemistry & Molecular Biology

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

Diji Kuriakose et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders

Tao Ming Sim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Nanomedicine for Ischemic Stroke

Xinyue Dong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

The role of microenvironment in tumor angiogenesis

Xianjie Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Chemistry, Multidisciplinary

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Simin Nazarnezhad et al.

NANOMATERIALS (2020)

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Review Pharmacology & Pharmacy

Manipulation of immune-vascular crosstalk: new strategies towards cancer treatment

Yang Zhao et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Cell Biology

Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment - New Findings and Future Perspectives

Laurenz Nagl et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Clinical Neurology

Pathophysiology of Blood-Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

Sara Bernardo-Castro et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Pharmacology & Pharmacy

Probing the drug delivery strategies in ischemic stroke therapy

Qiong Wu et al.

DRUG DELIVERY (2020)

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Review Nanoscience & Nanotechnology

Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?

Mojtaba Hoseini-Ghahfarokhi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Biochemistry & Molecular Biology

Nanomaterials for Cardiac Tissue Engineering

Devang R. Amin et al.

MOLECULES (2020)

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Review Immunology

Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells

Hisamichi Naito et al.

INTERNATIONAL IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects

Rui Zhao et al.

THERANOSTICS (2020)

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Review Cell Biology

Development of therapeutic antibodies for the treatment of diseases

Ruei-Min Lu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Nanotechnology for angiogenesis: opportunities and challenges

Saeid Kargozar et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Engineered Nanoparticles for Effective Redox Signaling During Angiogenic and Antiangiogenic Therapy

Susheel Kumar Nethi et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

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Article Engineering, Biomedical

HIF-prolyl hydroxylase 2 silencing using siRNA delivered by MRI-visible nanoparticles improves therapy efficacy of transplanted EPCs for ischemic stroke

Congxiao Wang et al.

BIOMATERIALS (2019)

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Article Engineering, Biomedical

Stimulus-activatable echogenic maltodextrin nanoparticles as nanotheranostic agents for peripheral arterial disease

Eunkyeong Jung et al.

BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

VEGF in Signaling and Disease: Beyond Discovery and Development

Rajendra S. Apte et al.

CELL (2019)

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Article Medicine, Research & Experimental

Fenofibrate-Loaded Biodegradable Nanoparticles for the Treatment of Experimental Diabetic Retinopathy and Neovascular Age-Related Macular Degeneration

Fangfang Qiu et al.

MOLECULAR PHARMACEUTICS (2019)

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Review Chemistry, Multidisciplinary

Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine

Moran Yadid et al.

NANO LETTERS (2019)

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Review Biotechnology & Applied Microbiology

Adeno-associated virus vector as a platform for gene therapy delivery

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NATURE REVIEWS DRUG DISCOVERY (2019)

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Magnetic Resonance Imaging or Computed Tomography Before Treatment in Acute Ischemic Stroke Effect on Workflow and Functional Outcome

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Silica-coated magnetic nanoparticles labeled endothelial progenitor cells alleviate ischemic myocardial injury and improve long-term cardiac function with magnetic field guidance in rats with myocardial infarction

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JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Recent Advances in Nanomedicine for Ischemic and Hemorrhagic Stroke

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STROKE (2019)

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Microvascular bioengineering: a focus on pericytes

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Graphene oxide: A growth factor delivery carrier to enhance chondrogenic differentiation of human mesenchymal stem cells in 3D hydrogels

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ACTA BIOMATERIALIA (2019)

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Review Nanoscience & Nanotechnology

Antiangiogenic properties of nanoparticles: a systematic review

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection

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Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

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Poly(lactic-co-glycolic acid) nanoparticle-mediated interleukin-12 delivery for the treatment of diabetic retinopathy

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ELIFE (2019)

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Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

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Current Therapeutic Strategies in Diabetic Foot Ulcers

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RGD-Modified Nanocarrier-Mediated Targeted Delivery of HIF-1α-AA Plasmid DNA to Cerebrovascular Endothelial Cells for Ischemic Stroke Treatment

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Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

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Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis

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JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Nanoparticles as new tools for inhibition of cancer angiogenesis

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Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke

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Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

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Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

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VEGF nanoparticles repair the heart after myocardial infarction

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Update on peripheral artery disease: Epidemiology and evidence-based facts

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ATHEROSCLEROSIS (2018)

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Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration

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Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

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Effects of VEGF-ANG-1-PLA nano-sustained release microspheres on proliferation and differentiation of ADSCs

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Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering

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Autophagy-mediated neuroprotection induced by octreotide in an ex vivo model of early diabetic retinopathy

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PHARMACOLOGICAL RESEARCH (2018)

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Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

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Development of K-doped ZnO nanoparticles encapsulated crosslinked chitosan based new membranes to stimulate angiogenesis in tissue engineered skin grafts

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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VEGF delivery by smart polymeric PNIPAM nanoparticles affects both osteogenic and angiogenic capacities of human bone marrow stem cells

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization-Induced Self-Assembly

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Promoted Angiogenesis and Osteogenesis by Dexamethasone-loaded Calcium Phosphate Nanoparticles/Collagen Composite Scaffolds with Microgroove Networks

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SCIENTIFIC REPORTS (2018)

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A novel strategy for in vivo angiogenesis and osteogenesis: magnetic micro-movement in a bone scaffold

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Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing

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Nanomedicine: Principles, Properties, and Regulatory Issues

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FRONTIERS IN CHEMISTRY (2018)

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Sequence-specific control of inorganic nanomaterials morphologies by biomolecules

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CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2018)

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Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing

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SCIENTIFIC REPORTS (2018)

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Increased osteogenic differentiation potential of MSCs cultured on nanofibrous structure through activation of Wnt/β-catenin signalling by inorganic polyphosphate

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Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway

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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Monitoring of tumor vascular normalization: the key points from basic research to clinical application

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Erythrosine Adsorption from Aqueous Solution via Decorated Graphene Oxide with Magnetic Iron Oxide Nano Particles: Kinetic and Equilibrium Studies

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SEMINARS IN INTERVENTIONAL RADIOLOGY (2018)

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Vascular Endothelial Growth Factor B and Its Signaling

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The Diagnostic Classification of Critical Limb Ischemia

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ANNALS OF VASCULAR DISEASES (2018)

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Dynamic imaging of allogeneic adipose-derived regenerative cells transplanted in ischemic hind limb of apolipoprotein E mouse model

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Interaction of hydroxyapatite nanoparticles with endothelial cells: internalization and inhibition of angiogenesis in vitro through the PI3K/Akt pathway

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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Role of tumor microenvironment in tumorigenesis

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JOURNAL OF CANCER (2017)

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Investigation of the role of nitric oxide driven angiogenesis by zinc oxide nanoflowers

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JOURNAL OF MATERIALS CHEMISTRY B (2017)

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The study of angiogenesis stimulated by multivalent peptide ligand-modified alginate

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COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Nano-shape varied cerium oxide nanomaterials rescue human dental stem cells from oxidative insult through intracellular or extracellular actions

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ACTA BIOMATERIALIA (2017)

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Improved vascularization of porous scaffolds through growth factor delivery from heparinized polyethylene glycol hydrogels

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ACTA BIOMATERIALIA (2017)

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Cerium Oxide Nanoparticle Modified Scaffold Interface Enhances Vascularization of Bone Grafts by Activating Calcium Channel of Mesenchymal Stem Cells

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The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment

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ACTA BIOMATERIALIA (2016)

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Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease

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Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair

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The roles of vascular endothelial growth factor in bone repair and regeneration

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BONE (2016)

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Nano-fibrin stabilized CaSO4 crystals incorporated injectable chitin composite hydrogel for enhanced angiogenesis & osteogenesis

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Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

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H2O2-responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Gold nanoparticles: A critical review of therapeutic applications and toxicological aspects

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JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2016)

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Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine

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Distribution of Systemically Administered Nanoparticles Reveals a Size-Dependent Effect Immediately following Cardiac Ischaemia-Reperfusion Injury

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SCIENTIFIC REPORTS (2016)

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A vascular tissue engineering scaffold with core-shell structured nano-fibers formed by coaxial electrospinning and its biocompatibility evaluation

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BIOMEDICAL MATERIALS (2016)

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Nanoscale Strategies: Treatment for Peripheral Vascular Disease and Critical Limb Ischemia

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ACS NANO (2015)

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Review Peripheral Vascular Disease

The pathogenic role of angiogenesis in rheumatoid arthritis

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ANGIOGENESIS (2015)

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Enhancing neurogenesis and angiogenesis with target delivery of stromal cell derived factor-1 alpha using a dual ionic pH-sensitive copolymer

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Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis

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Gold nanoparticles with different charge and moiety induce differential cell response on mesenchymal stem cell osteogenesis

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Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair

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MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma

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JOURNAL OF CONTROLLED RELEASE (2015)

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Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction

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MOLECULAR MEDICINE REPORTS (2015)

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Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles

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THERANOSTICS (2015)

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Review Biotechnology & Applied Microbiology

Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling

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BIOMED RESEARCH INTERNATIONAL (2015)

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Review Pharmacology & Pharmacy

HIF-1α pathway: role, regulation and intervention for cancer therapy

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ACTA PHARMACEUTICA SINICA B (2015)

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Folate-conjugated albumin nanoparticles for rheumatoid arthritis-targeted delivery of etoricoxib

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Clinical Characteristics and Current Treatment of Age-Related Macular Degeneration

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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

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Recent advances in the diagnosis and treatment of acute myocardial infarction

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WORLD JOURNAL OF CARDIOLOGY (2015)

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Fibroblast Growth Factor Signaling Pathway in Endothelial Cells Is Activated by BMPER to Promote Angiogenesis

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications

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Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis

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ACS NANO (2014)

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Nanomedicine: Tiny Particles and Machines Give Huge Gains

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ANNALS OF BIOMEDICAL ENGINEERING (2014)

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Overcoming disease-induced growth factor resistance in therapeutic angiogenesis using recombinant co-receptors delivered by a liposomal system

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BIOMATERIALS (2014)

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Covalent immobilisation of VEGF on plasma-coated electrospun scaffolds for tissue engineering applications

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Gene therapy for peripheral arterial disease

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EXPERT OPINION ON BIOLOGICAL THERAPY (2014)

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Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors

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JOURNAL OF CONTROLLED RELEASE (2014)

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Effect of silica nanoparticles with variable size and surface functionalization on human endothelial cell viability and angiogenic activity

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Anti-Angiogenesis Effect of Biogenic Silver Nanoparticles Synthesized Using Saliva officinalis on Chick Chorioalantoic Membrane (CAM)

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MOLECULES (2014)

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Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes

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NANO RESEARCH (2014)

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Anti-angiogenic effect of bare titanium dioxide nanoparticles on pathologic neovascularization without unbearable toxicity

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Imaging of Oxidation-Specific Epitopes with Targeted Nanoparticles to Detect High-Risk Atherosclerotic Lesions: Progress and Future Directions

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JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2014)

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Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia

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SCIENTIFIC REPORTS (2014)

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Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

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Article Medicine, Research & Experimental

Image-guided Pro-angiogenic Therapy in Diabetic Stroke Mouse Models Using a Multi-modal Nanoprobe

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THERANOSTICS (2014)

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Review Dermatology

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair

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ADVANCES IN WOUND CARE (2014)

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Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional Nanoparticles

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Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration

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ACS NANO (2013)

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Article Engineering, Biomedical

Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect

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ACTA BIOMATERIALIA (2013)

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Review Peripheral Vascular Disease

Therapeutic Angiogenesis in Critical Limb Ischemia

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ANGIOLOGY (2013)

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Article Engineering, Biomedical

Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity

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BIOMATERIALS (2013)

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Article Engineering, Biomedical

Osteogenesis and angiogenesis induced by porous beta-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways

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Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics

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BIOMATERIALS (2013)

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Induction of Angiogenesis by Controlled Delivery of Vascular Endothelial Growth Factor Using Nanoparticles

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CARDIOVASCULAR THERAPEUTICS (2013)

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Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis

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CHEMICAL COMMUNICATIONS (2013)

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Synthesis, characterization and in vitro studies of celecoxib-loaded poly(ortho ester) nanoparticles targeted for intraocular drug delivery

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COLLOIDS AND SURFACES B-BIOINTERFACES (2013)

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Article Biotechnology & Applied Microbiology

Functionalization of electrospun poly(ε-caprolactone) scaffold with heparin and vascular endothelial growth factors for potential application as vascular grafts

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JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2013)

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Article Nanoscience & Nanotechnology

Gold Nanoparticles Induce Nanostructural Reorganization of VEGFR2 to Repress Angiogenesis

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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2013)

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Article Medicine, Research & Experimental

Transcriptional Responses of Human Aortic Endothelial Cells to Nanoconstructs Used in Biomedical Applications

Philip J. Moos et al.

MOLECULAR PHARMACEUTICS (2013)

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Article Chemistry, Multidisciplinary

VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle

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NANOSCALE (2013)

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Review Cell Biology

Angiogenesis and Its Therapeutic Opportunities

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MEDIATORS OF INFLAMMATION (2013)

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Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer

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PLOS ONE (2013)

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Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Multidisciplinary Sciences

Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle

Rochelle R. Arvizo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Cell & Tissue Engineering

Stem Cell Regenerative Potential Combined with Nanotechnology and Tissue Engineering for Myocardial Regeneration

Manuela Calin et al.

CURRENT STEM CELL RESEARCH & THERAPY (2013)

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Article Nanoscience & Nanotechnology

Comparison of anti-angiogenic properties of pristine carbon nanoparticles

Mateusz Wierzbicki et al.

NANOSCALE RESEARCH LETTERS (2013)

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Silicate bioceramics induce angiogenesis during bone regeneration

Wanyin Zhai et al.

ACTA BIOMATERIALIA (2012)

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Article Engineering, Biomedical

Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels

Shuhui He et al.

ACTA BIOMATERIALIA (2012)

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Article Chemistry, Multidisciplinary

Ceria Nanoparticles that can Protect against Ischemic Stroke

Chi Kyung Kim et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments

Soumen Das et al.

BIOMATERIALS (2012)

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Article Chemistry, Organic

Fast and efficient method for the synthesis of 2-arylbenzimidazoles using MCM-41-SO3H

Gholam Hossein Mahdavinia et al.

HETEROCYCLIC COMMUNICATIONS (2012)

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Editorial Material Medicine, General & Internal

Mixed Results for Bone Marrow-Derived Cell Therapy for Ischemic Heart Disease

Eduardo Marban et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

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Article Medicine, Research & Experimental

Systemic Delivery Systems of Angiogenic Gene by Novel Bubble Liposomes Containing Cationic Lipid and Ultrasound Exposure

Yoichi Negishi et al.

MOLECULAR PHARMACEUTICS (2012)

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Review Chemistry, Multidisciplinary

Multifunctional nanoscale strategies for enhancing and monitoring blood vessel regeneration

Eunna Chung et al.

NANO TODAY (2012)

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Article Nanoscience & Nanotechnology

Antiangiogenic effect of silicate nanoparticle on retinal neovascularization induced by vascular endothelial growth factor

Dong Hyun Jo et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

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STRONG NEUROPROTECTION WITH A NOVEL PLATINUM NANOPARTICLE AGAINST ISCHEMIC STROKE- AND TISSUE PLASMINOGEN ACTIVATOR-RELATED BRAIN DAMAGES IN MICE

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NEUROSCIENCE (2012)

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Article Multidisciplinary Sciences

Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Review Medicine, Research & Experimental

Therapeutic Angiogenesis for Treating Cardiovascular Diseases

Lorenzo Deveza et al.

THERANOSTICS (2012)

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Review Peripheral Vascular Disease

A Review of the Role of Anticoagulation in the Treatment of Peripheral Arterial Disease

Thomas F. Whayne

INTERNATIONAL JOURNAL OF ANGIOLOGY (2012)

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Article Cell & Tissue Engineering

CONTROL OF MICROENVIRONMENTAL CUES WITH A SMART BIOMATERIAL COMPOSITE PROMOTES ENDOTHELIAL PROGENITOR CELL ANGIOGENESIS

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EUROPEAN CELLS & MATERIALS (2012)

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Therapeutic angiogenesis: controlled delivery of angiogenic factors

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THERAPEUTIC DELIVERY (2012)

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Phase I/IIa Clinical Trial of Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer to Treat Critical Limb Ischemia

Ryuichi Morishita et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

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The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation

Jin Hyoung Kim et al.

BIOMATERIALS (2011)

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Heart Disease and Stroke Statistics-2011 Update A Report From the American Heart Association

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CIRCULATION (2011)

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Neurological and Pathological Improvements of Cerebral Infarction in Mice With Platinum Nanoparticles

Motonori Takamiya et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2011)

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Article Cardiac & Cardiovascular Systems

Targeted Iron Oxide Particles for In Vivo Magnetic Resonance Detection of Atherosclerotic Lesions With Antibodies Directed to Oxidation-Specific Epitopes

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis

Jaeyun Kim et al.

NANO LETTERS (2011)

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Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

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Review Multidisciplinary Sciences

Molecular mechanisms and clinical applications of angiogenesis

Peter Carmeliet et al.

NATURE (2011)

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Review Clinical Neurology

Intravenous Thrombolytics for Ischemic Stroke

Andrew D. Barreto

NEUROTHERAPEUTICS (2011)

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Article Chemistry, Multidisciplinary

Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure

Yoichi Negishi et al.

PHARMACEUTICAL RESEARCH (2011)

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Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Acute Myocardial Infarction in Rats

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JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

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Review Cell & Tissue Engineering

Nanotechnology-mediated targeting of tumor angiogenesis

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VASCULAR CELL (2011)

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Shape Effect of Carbon Nanovectors on Angiogenesis

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ACS NANO (2010)

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Article Cardiac & Cardiovascular Systems

Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis

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CIRCULATION (2010)

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Review Biotechnology & Applied Microbiology

Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy

Conrad P. Hodgkinson et al.

HUMAN GENE THERAPY (2010)

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Editorial Material Chemistry, Multidisciplinary

Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting

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JOURNAL OF CONTROLLED RELEASE (2010)

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Review Chemistry, Multidisciplinary

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

Fabienne Danhier et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Medicine, Research & Experimental

Nanoparticles Based on PLGA:Poloxamer Blends for the Delivery of Proangiogenic Growth Factors

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MOLECULAR PHARMACEUTICS (2010)

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Article Peripheral Vascular Disease

Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis

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ANGIOGENESIS (2009)

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Article Chemistry, Multidisciplinary

Silica supported ammonium dihydrogen phosphate (NH4H2PO4/SiO2): A mild, reusable and highly efficient heterogeneous catalyst for the synthesis of 14-aryl-14-H-dibenzo[a,j]xanthenes

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CHINESE CHEMICAL LETTERS (2009)

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Article Cardiac & Cardiovascular Systems

Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell-Based Myocardial Salvage After Acute Myocardial Infarction

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CIRCULATION (2009)

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Review Cardiac & Cardiovascular Systems

Human Studies of Angiogenic Gene Therapy

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CIRCULATION RESEARCH (2009)

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Article Endocrinology & Metabolism

Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage

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DIABETES (2009)

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Article Cardiac & Cardiovascular Systems

Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats

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EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2009)

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Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat

Seong-Keun Moon et al.

EXPERIMENTAL NEUROLOGY (2009)

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Article Chemistry, Organic

Solvent-Free Chemoselective Synthesis of Some Novel Substituted 2-Arylbenzimidazoles Using Amino Acid-Based Prolinium Nitrate Ionic Liquid as Catalyst

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JOURNAL OF HETEROCYCLIC CHEMISTRY (2009)

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In Situ Loading of Basic Fibroblast Growth Factor Within Porous Silica Nanoparticles for a Prolonged Release

Jin Zhang et al.

NANOSCALE RESEARCH LETTERS (2009)

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In vitro free radical scavenging activity of platinum nanoparticles

Aki Watanabe et al.

NANOTECHNOLOGY (2009)

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Angiogenesis in Calcium Phosphate Scaffolds by Inorganic Copper Ion Release

Jake Barralet et al.

TISSUE ENGINEERING PART A (2009)

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Copper Regulation of Hypoxia-Inducible Factor-1 Activity

Wenke Feng et al.

MOLECULAR PHARMACOLOGY (2009)

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Review Cardiac & Cardiovascular Systems

Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy

Tetsuji Miura et al.

BASIC RESEARCH IN CARDIOLOGY (2008)

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Nano sphere-mediated deliver of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs

Sun-Woong Kang et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy

Jong-Ho Kim et al.

BIOMATERIALS (2008)

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Aqueous NaHSO4 catalyzed regioselective and versatile synthesis of 2-thiazolamines

Shahnaz Rostamizadeh et al.

MONATSHEFTE FUR CHEMIE (2008)

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Vascular endothelial growth factor in eye disease

J. S. Penn et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2008)

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Integrins in angiogenesis and lymphangiogenesis

Christie J. Avraamides et al.

NATURE REVIEWS CANCER (2008)

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Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke

Andreas Saleh et al.

STROKE (2007)

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Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI

Vardan Amirbekian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Inter-society consensus for the management of peripheral arterial disease (TASC II)

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JOURNAL OF VASCULAR SURGERY (2007)

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Prosthetic vascular grafts: Wrong models, wrong questions and no healing

Peter Zilla et al.

BIOMATERIALS (2007)

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Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation

Zhifeng Xiao et al.

CELL RESEARCH (2007)

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Article Hematology

Endothelial αvβ3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis

Patrick M. Winter et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Article Endocrinology & Metabolism

Risk factors for foot infections in individuals with diabetes

Lawrence A. Lavery et al.

DIABETES CARE (2006)

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Review Biotechnology & Applied Microbiology

Design and development of polymers for gene delivery

DW Pack et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

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Release of angiogenic growth factors from cells encapsulated in alginate beads with bioactive glass

H Keshaw et al.

BIOMATERIALS (2005)

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Vascular endothelial growth factor gene delivery by magnetic DNA nanospheres ameliorates limb ischemia in rabbits

HC Jiang et al.

JOURNAL OF SURGICAL RESEARCH (2005)

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Review Biochemistry & Molecular Biology

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

M Presta et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2005)

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Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470

R Satchi-Fainaro et al.

NATURE MEDICINE (2004)

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Survival in patients with peripheral vascular disease after percutaneous coronary intervention and coronary artery bypass graft surgery

DJ O'Rourke et al.

ANNALS OF THORACIC SURGERY (2004)

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Article Engineering, Biomedical

Endothelial and vascular smooth muscle cell function on poly(lactic-co-glycolic acid) with nano-structured surface features

DC Miller et al.

BIOMATERIALS (2004)

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Article Biochemistry & Molecular Biology

Cobalt induces hypoxia-inducible factor-1α expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism

G Chachami et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)

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Article Pathology

Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells

RD Galiano et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

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Article Biochemistry & Molecular Biology

High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro

JAM Maier et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2004)

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Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways

P Baluk et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

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Review Gastroenterology & Hepatology

Mechanism and its regulation of tumor-induced angiogenesis

MK Gupta et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2003)

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Article Biochemistry & Molecular Biology

Fibroblast growth factor-4 induces vascular permeability, angiogenesis, and arteriogenesis in a rabbit hind limb ischemia model

TT Rissanen et al.

FASEB JOURNAL (2002)

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Article Endocrinology & Metabolism

Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats

D Zhang et al.

DIABETOLOGIA (2001)

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Review Cardiac & Cardiovascular Systems

Therapeutic angiogenesis for ischemic cardiovascular disease

SB Freedman et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2001)

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Article Endocrinology & Metabolism

Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers - A prospective randomized multicenter clinical trial

A Veves et al.

DIABETES CARE (2001)

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Article Cardiac & Cardiovascular Systems

Basic fibroblast growth factor in patients with intermittent claudication: Results of a phase I trial

DF Lazarous et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2000)

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