☆ 4.6 Article

Synthesis of push-pull-activated ynol ethers and their evaluation in the bioorthogonal hydroamination reaction

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Bioorthogonal click and release: A general, rapid, chemically revertible bioconjugation strategy employing enamine N-oxides

Dahye Kang et al.

Summary: This article describes a chemically revertible bioconjugation strategy using enamine N-oxides for a bio-orthogonal dissociative reaction. The reaction is rapid, complete, and relatively insensitive to common buffers and pH levels. It can be paired with a bioorthogonal hydroamination reaction to create an integrated click and release system.

CHEM (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions

Titas Deb et al.

Summary: This article reviews the mechanisms and substituent effects of some of the principal metal-free bioorthogonal reactions, based on inverse-electron demand Diels-Alder reactions, 1,3-dipolar cycloadditions, and the Staudinger reaction. Modified versions that link these reactions to a dissociative step are further discussed, with the aim to aid the advancement of bioorthogonal chemistry.

CHEMICAL REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioorthogonal Retro-Cope Elimination Reaction of N,N-Dialkylhydroxylamines and Strained Alkynes

Dahye Kang et al.

Summary: This study describes a bioorthogonal reaction between N,N-dialkylhydroxylamines and cyclooctynes, which features highly regioselective transformation, fast rate, high stability, and excellent chemoselectivity in cell lysate. This reaction introduces a new member to the bioorthogonal reaction compendium outside the prolific class of cycloaddition reactions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents

Dahye Kang et al.

Summary: Tumor hypoxia-induced adaptive reprogramming of cancer cells can lead to poor prognosis, making hypoxia-activated prodrug development challenging. A novel hypoxia-responsive trigger derived from enamine N-oxide structures was synthesized and applied for hypoxia-activated prodrug and tumor labeling. The versatile enamine N-oxide motif with dual drug release and imaging modalities presents an attractive opportunity for theranostic development to address the needs for new therapeutics and patient stratification.

ACS CENTRAL SCIENCE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioorthogonal Hydroamination of Push-Pull-Activated Linear Alkynes

Dahye Kang et al.

Summary: This study presents a bioorthogonal reaction between N,N-dialkylhydroxylamines and push-pull-activated halogenated alkynes. By utilizing rehybridization effects to activate alkynes and balancing stereoelectronic and inductive factors, the reaction successfully protects alkynes from cellular nucleophiles while maintaining sufficient kinetics and stability.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Polymer Science

The CuAAC: Principles, Homogeneous and Heterogeneous Catalysts, and Novel Developments and Applications

Steve Neumann et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Zinc-Catalyzed Asymmetric Formal [4+3] Annulation of Isoxazoles with Enynol Ethers by 6π Electrocyclization: Stereoselective Access to 2H-Azepines

Xin-Qi Zhu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Triple, Mutually Orthogonal Bioorthogonal Pairs through the Design of Electronically Activated Sulfamate-Containing Cycloalkynes

Yun Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state

Jerrin Thomas George et al.

CHEMICAL COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Strain and stereoelectronics in cycloalkyne click chemistry

Trevor Harris et al.

MENDELEEV COMMUNICATIONS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Click Chemistry as a Tool for Cell Engineering and Drug Delivery

Yukiya Takayama et al.

MOLECULES (2019)

添加到收藏夹

Review Cell Biology

Novel lipid tools and probes for biological investigations

Aurelien Laguerre et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stereoelectronic Chameleons: The Donor-Acceptor Dichotomy of Functional Groups

Sergey Z. Vatsadze et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrafast Click Chemistry with Fluorosydnones

Hui Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

2-Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification

Andras Herner et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Organic

Orbital hybridization: a key electronic factor in control of structure and reactivity

Igor V. Alabugin et al.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Click Chemistry in Materials Science

Weixian Xi et al.

ADVANCED FUNCTIONAL MATERIALS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

The synthesis and structure of chiral enamine N-oxides

I. A. O'Neil et al.

CHEMICAL COMMUNICATIONS (2014)

添加到收藏夹

Article Chemistry, Organic

Synthesis of Alkyl-Ynol-Ethers by Anti-Michael Addition of Metal Alkoxides to -Substituted Alkynylsulfones

Leyre Marzo et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Moderating Strain without Sacrificing Reactivity: Design of Fast and Tunable Noncatalyzed Alkyne-Azide Cycloadditions via Stereoelectronically Controlled Transition State Stabilization

Brian Gold et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Chemistry, Organic

Selective Transition State Stabilization via Hyperconjugative and Conjugative Assistance: Stereoelectronic Concept for Copper-Free Click Chemistry

Brian Gold et al.

JOURNAL OF ORGANIC CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

David M. Patterson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

Jan Dommerholt et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

John C. Jewett et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemical Approaches To Perturb, Profile, and Perceive Glycans

Nicholas J. Agard et al.

ACCOUNTS OF CHEMICAL RESEARCH (2009)

添加到收藏夹

Review Chemistry, Multidisciplinary

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

添加到收藏夹

Article Biochemical Research Methods

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

Neal K. Devaraj et al.

BIOCONJUGATE CHEMISTRY (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tetrazine ligation: Fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity

Melissa L. Blackman et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Copper-free click chemistry for dynamic in vivo imaging

Jeremy M. Baskin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Review Chemistry, Multidisciplinary

The growing applications of click chemistry

John E. Moses et al.

CHEMICAL SOCIETY REVIEWS (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.