期刊
ACS MATERIALS LETTERS
卷 4, 期 11, 页码 2210-2218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmaterialslett.2c00698
关键词
-
资金
- Natural Science Foundation of Hebei Province of China
- [H2020202002]
In this study, a novel bendable helix conduit was fabricated using a combination of electrohydrodynamic printing and electrospinning. The conduit showed excellent flexibility, stability, and adsorption capacity, making it a promising option for clinical treatment of peripheral nerve injuries.
Nerve guidance conduits (NGCs) are considered as the best alternative approach to autologous nerve grafting for treating peripheral nerve injuries (PNI). The bendable NGCs are desirable in practical use but are still difficult to fabricate. In this study, the hybrid electrotechnologies combining electrohydrody-namic (EHD) printing and electrospinning were applied to produce a novel bendable helix conduit with tunable flexibility. Helical polycaprolactone (PCL) foundations were constructed via EHD printing for mechanical support, on which electrospinning PCL membrane was coated to form the bendable helix conduits and keep the entire structure stable. The effects of helical foundation with different helical height on the properties of NGCs were analyzed. In addition, these three-dimensional (3D) bendable helix conduits had excellent resistance to compression and fatigue. Moreover, the bendable conduits had higher specific surface area, which is beneficial to the adsorption of RSC96 cells. Therefore, the 3D bendable helix conduits show great potential in clinical application for treating PNI.
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