Merging photoredox with copper catalysis: enantioselective remote cyanation via 1,4-heteroaryl migration

We have developed a photoredox/Cu dual catalyzed enantioselective remote cyanation via 1,4-heteroaryl migration. Experimental and computational studies have been carried out to reveal the reaction mechanism and explain the origins of the regio- and enantioselectivities of the remote cyanation process. This methodology exhibits mild conditions, a broad substrate scope and good regio- and enantioselectivities, which provides a unique approach for catalyst-controlled asymmetric backbone recombination of molecules via functional group migration.

Automated summary

A photoredox/Cu dual catalyzed enantioselective remote cyanation via 1,4-heteroaryl migration has been developed. Experimental and computational studies were conducted to explore the reaction mechanism and explain the origin of regio- and enantioselectivities. This methodology demonstrates mild conditions, a wide substrate scope and good selectivities, providing a unique approach to catalyst-controlled asymmetric backbone recombination via functional group migration.