期刊
BIOMATERIALS ADVANCES
卷 143, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bioadv.2022.213160
关键词
Polyetheretherketone; Osteogenesis; Angiogenesis; Anti-inflammatory
资金
- National Key Research and Development Program of China
- Na-tional Foundation of Science and Technology
- Shenzhen Science and Technology Innovation Committee
- Doctor of Innovation and Entrepreneur-ship in Jiangsu Province
- [2019YFA0906004]
- [11872200]
- [JSGG20200225151916021]
- [JSSCBS20210911]
PEEK modified with Sr2+ has triple functions of promoting osteogenesis, angiogenesis, and anti-inflammatory, showing great promise for bone repair applications.
Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good me-chanical properties. However, the biological inertness of PEEK limits its clinical application. Sr2+ has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflam-mation. In this paper, PEEK was modified with Sr2+ with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr2+ for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr2+ should show great promise for clinical applications in bone repair.
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