4.7 Article

A triphenylphosphine coordinated Cu(I) Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy

期刊

DALTON TRANSACTIONS
卷 51, 期 47, 页码 18054-18058

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt03088h

关键词

-

资金

  1. National Natural Science Foundation of China
  2. [22075056]
  3. [21861005]

向作者/读者索取更多资源

A novel copper complex Fc-OD-Cu was synthesized and designed for efficient chemodynamic therapy. Fc-OD-Cu can generate highly reactive hydroxyl radicals through a reaction induced by copper moieties, resulting in higher therapeutic efficiency compared to other compounds.
A triphenylphosphine coordinated Cu(i) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (OH) via a Fenton-like reaction induced by Cu(i) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(i) moieties).

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据