4.8 Article

Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Eugen Dhimolea et al.

Summary: Our study reveals that treatment-persistent tumor cells in cancer patients adopt a reversible transcriptional program similar to embryonic diapause, which allows them to resist chemotherapy-induced cytotoxicity. Inhibiting Myc activity or interfering with the diapause-like adaptation could be potential therapeutic strategies against chemotherapy-persistent tumor cells.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Sumaiyah K. Rehman et al.

Summary: It has been discovered that cancer cells enter a drug-tolerant persister state to evade treatment, showing similarities with diapause in embryonic development. All cancer cells possess the potential to become drug-tolerant persisters, rather than just a small subpopulation.
Article Multidisciplinary Sciences

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

Baihao Zhang et al.

Summary: This study reveals that small metabolites like GABA derived from B-lineage cells can influence immune responses by promoting anti-inflammatory macrophages and enhancing anti-tumour responses. The findings suggest that targeting these metabolites may offer a new approach to immunoregulation.

NATURE (2021)

Article Oncology

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

Oskar Marin-Bejar et al.

Summary: Therapy resistance in melanoma can arise from genetic or nongenetic mechanisms, with the emergence of neural crest stem cells in minimal residual disease playing a role in the development of nongenetic resistance. Ablation of these cells through focal adhesion kinase inhibition delays tumor relapse and reveals that ultimately resistant tumors exhibit genetic alterations that increase sensitivity to specific inhibitors.

CANCER CELL (2021)

Review Biochemistry & Molecular Biology

Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors

Masato Mashimo et al.

Summary: Acetylcholine, traditionally known as a neurotransmitter, has been found to regulate immune cell functions through muscarinic and nicotinic ACh receptors. It impacts the activities of T cells, B cells, and macrophages, affecting both innate and acquired immunity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Cycling cancer persister cells arise from lineages with distinct programs

Yaara Oren et al.

Summary: Recent studies have revealed that cancer cells can enter different lineages in response to treatment, with distinct biological characteristics and metabolic programs. Proliferative capacity of drug-tolerant persister cells is associated with upregulation of antioxidant gene programs and a metabolic shift to fatty acid oxidation.

NATURE (2021)

Review Biochemistry & Molecular Biology

Neurotransmitters: emerging targets in cancer

Shu-Heng Jiang et al.

ONCOGENE (2020)

Review Biotechnology & Applied Microbiology

The great escape: tumour cell plasticity in resistance to targeted therapy

Soufiane Boumahdi et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Biochemistry & Molecular Biology

Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression

Mong-Lien Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Persistent Cancer Cells: The Deadly Survivors

Shensi Shen et al.

Review Oncology

Nerves in cancer

Ali H. Zahalka et al.

NATURE REVIEWS CANCER (2020)

Review Pharmacology & Pharmacy

Acetylcholine signaling system in progression of lung cancers

Jamie R. Friedman et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Multidisciplinary Sciences

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey et al.

NATURE (2019)

Article Multidisciplinary Sciences

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer

Yasuhiro Saito et al.

NATURE (2019)

Article Multidisciplinary Sciences

Electrical and synaptic integration of glioma into neural circuits

Humsa S. Venkatesh et al.

NATURE (2019)

Article Multidisciplinary Sciences

Glutamatergic synaptic input to glioma cells drives brain tumour progression

Varun Venkataramani et al.

NATURE (2019)

Article Multidisciplinary Sciences

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Qiqun Zeng et al.

NATURE (2019)

Article Multidisciplinary Sciences

Adaptive mutability of colorectal cancers in response to targeted therapies

Mariangela Russo et al.

SCIENCE (2019)

Article Oncology

Acetylcholine receptors: Key players in cancer development

Jiawei Chen et al.

SURGICAL ONCOLOGY-OXFORD (2019)

Review Immunology

Alternative mRNA splicing in cancer immunotherapy

Luke Frankiw et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Toward Minimal Residual Disease-Directed Therapy in Melanoma

Florian Rambow et al.

Article Multidisciplinary Sciences

Histidine catabolism is a major determinant of methotrexate sensitivity

Naama Kanarek et al.

NATURE (2018)

Article Multidisciplinary Sciences

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Benjamin D. Hopkins et al.

NATURE (2018)

Article Multidisciplinary Sciences

Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

Rajeswara Rao Arasada et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

Brian Biehs et al.

NATURE (2018)

Article Multidisciplinary Sciences

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

Adriana Sanchez-Danes et al.

NATURE (2018)

Review Oncology

Targeting minimal residual disease: a path to cure?

Marlise R. Luskin et al.

NATURE REVIEWS CANCER (2018)

Review Medicine, General & Internal

Lung cancer: current therapies and new targeted treatments

Fred R. Hirsch et al.

LANCET (2017)

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

Review Oncology

Understanding and targeting resistance mechanisms in NSCLC

Julia Rotow et al.

NATURE REVIEWS CANCER (2017)

Article Biotechnology & Applied Microbiology

Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase

Peder S. Olofsson et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Maia Vinogradova et al.

NATURE CHEMICAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Michael Ramirez et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Alternative Wnt Signaling Activates YAP/TAZ

Hyun Woo Park et al.

Article Biochemistry & Molecular Biology

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

Giorgio G. Galli et al.

MOLECULAR CELL (2015)

Article Genetics & Heredity

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Claudia Stein et al.

PLOS GENETICS (2015)

Article Oncology

The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi et al.

NATURE REVIEWS CANCER (2015)

Review Biochemistry & Molecular Biology

Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review

Minseong Kim et al.

BMB REPORTS (2014)

Article Biochemistry & Molecular Biology

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

Luca Azzolin et al.

Article Medicine, Research & Experimental

Cholinergic Receptors as Target for Cancer Therapy in a Systems Medicine Perspective

P. Russo et al.

CURRENT MOLECULAR MEDICINE (2014)

Review Biotechnology & Applied Microbiology

Can we safely target the WNT pathway?

Michael Kahn

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

Leanne Li et al.

Article Multidisciplinary Sciences

Restriction of intestinal stem cell expansion and the regenerative response by YAP

Evan R. Barry et al.

NATURE (2013)

Article Multidisciplinary Sciences

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Ravid Straussman et al.

NATURE (2012)

Article Multidisciplinary Sciences

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

Mauricio Rosas-Ballina et al.

SCIENCE (2011)

Review Oncology

Choline metabolism in malignant transformation

Kristine Glunde et al.

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma et al.

Review Pharmacology & Pharmacy

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

I. Wessler et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Multidisciplinary Sciences

Alternative isoform regulation in human tissue transcriptomes

Eric T. Wang et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis

X. Li et al.

ONCOGENE (2008)

Review Pharmacology & Pharmacy

The clinical pharmacokinetics of darifenacin

A Skerjanec

CLINICAL PHARMACOKINETICS (2006)