4.7 Article

The rates of Cu(ii)-ATCUN complex formation. Why so slow?

期刊

DALTON TRANSACTIONS
卷 51, 期 46, 页码 17553-17557

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt02856e

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  1. National Science Centre of Poland (NCN) [2018/31/N/ST5/02556]
  2. Centre for Preclinical Research and Technology (CePT)
  3. European Regional Development Fund and Innovative Economy
  4. National Cohesion Strategy of Poland

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We investigated the kinetics of Cu(ii) binding to ACTUN peptides using modified/substituted GGH analogues. Rules for rate modulation by 1(st) and 2(nd) sphere interactions were established, providing crucial insight into the elucidation of the reaction mechanism and its contribution to biological copper transport.
We used a series of modified/substituted GGH analogues to investigate the kinetics of Cu(ii) binding to ACTUN peptides. Rules for rate modulation by 1(st) and 2(nd) sphere interactions were established, providing crucial insight into elucidation of the reaction mechanism and its contribution to biological copper transport.

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