Transition metal-free annulative vinylene transfer via the 1,3-dipolar reaction of N-ylides: access to benzo-fused indolizines

An efficient metal-free annulative vinylene transfer protocol for the synthesis of benzo-fused indolizines via 1,3-dipolar cycloadditions of N-ylides with vinylene carbonate has been developed. Vinylene carbonate serves as an acetylene surrogate without any external oxidant involved. This transformation leads to the direct construction of versatile benzo-fused indolizine derivatives in moderate to good yields.

Automated summary

An efficient metal-free protocol for the synthesis of benzo-fused indolizines has been developed using 1,3-dipolar cycloadditions of N-ylides with vinylene carbonate. Vinylene carbonate serves as an acetylene surrogate without the need for an external oxidant. This transformation allows for the direct construction of versatile benzo-fused indolizine derivatives in moderate to good yields.